The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases
Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …
research as we are still struggling to understand the interface between the aging process …
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
Detailed characterization of the cell types in the human brain requires scalable experimental
approaches to examine multiple aspects of the molecular state of individual cells, as well as …
approaches to examine multiple aspects of the molecular state of individual cells, as well as …
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
The human brain has enormously complex cellular diversity and connectivities fundamental
to our neural functions, yet difficulties in interrogating individual neurons has impeded …
to our neural functions, yet difficulties in interrogating individual neurons has impeded …
Worse than the disease? Reviewing some possible unintended consequences of the mRNA vaccines against COVID-19
S Seneff, G Nigh - International Journal of Vaccine Theory, Practice, and …, 2021 - ijvtpr.com
Operation Warp Speed brought to market in the United States two mRNA vaccines,
produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these …
produced by Pfizer and Moderna. Interim data suggested high efficacy for both of these …
A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA
Significant heterogeneities in gene expression among individual cells are typically
interrogated using single whole cell approaches. However, tissues that have highly …
interrogated using single whole cell approaches. However, tissues that have highly …
Somatic APP gene recombination in Alzheimer's disease and normal neurons
The diversity and complexity of the human brain are widely assumed to be encoded within a
constant genome. Somatic gene recombination, which changes germline DNA sequences to …
constant genome. Somatic gene recombination, which changes germline DNA sequences to …
Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …
Somatic mosaicism: implications for disease and transmission genetics
Nearly all of the genetic material among cells within an organism is identical. However,
single-nucleotide variants (SNVs), small insertions/deletions (indels), copy-number variants …
single-nucleotide variants (SNVs), small insertions/deletions (indels), copy-number variants …
Infectious origin of Alzheimer's disease: Amyloid beta as a component of brain antimicrobial immunity
I Vojtechova, T Machacek, Z Kristofikova… - PLoS …, 2022 - journals.plos.org
The amyloid cascade hypothesis, focusing on pathological proteins aggregation, has so far
failed to uncover the root cause of Alzheimer's disease (AD), or to provide an effective …
failed to uncover the root cause of Alzheimer's disease (AD), or to provide an effective …