Sustainability challenges in peptide synthesis and purification: from R&D to production

A Isidro-Llobet, MN Kenworthy… - The Journal of …, 2019 - ACS Publications
In recent years, there has been a growing interest in therapeutic peptides within the
pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 …

Peptide-drug conjugates and their targets in advanced cancer therapies

P Hoppenz, S Els-Heindl, AG Beck-Sickinger - Frontiers in chemistry, 2020 - frontiersin.org
Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

[HTML][HTML] Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?

C Fu, L Yu, Y Miao, X Liu, Z Yu, M Wei - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Peptide–drug conjugates (PDCs) are the next generation of targeted therapeutics drug after
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …

Peptide chemistry toolbox–Transforming natural peptides into peptide therapeutics

M Erak, K Bellmann-Sickert, S Els-Heindl… - Bioorganic & medicinal …, 2018 - Elsevier
The development of solid phase peptide synthesis has released tremendous opportunities
for using synthetic peptides in medicinal applications. In the last decades, peptide …

Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery

MK Tripathi, A Nath, TP Singh, AS Ethayathulla… - Molecular Diversity, 2021 - Springer
The accumulation of massive data in the plethora of Cheminformatics databases has made
the role of big data and artificial intelligence (AI) indispensable in drug design. This has …

The road to the synthesis of “difficult peptides”

M Paradís-Bas, J Tulla-Puche, F Albericio - Chemical Society Reviews, 2016 - pubs.rsc.org
The last decade has witnessed a renaissance of peptides as drugs. This progress, together
with advances in the structural behavior of peptides, has attracted the interest of the …

Polysaccharide–peptide conjugates: a versatile material platform for biomedical applications

HQ Song, Y Fan, Y Hu, G Cheng… - Advanced Functional …, 2021 - Wiley Online Library
Natural polymers, such as polysaccharides and proteins, have been widely studied for
numerous biomedical applications because of their bioactivity, natural origin, and …

Molecular characteristics and structure–activity relationships of food-derived bioactive peptides

FJ Yang, C Xu, MC Huang, Y Qian, XX Cai… - Journal of Integrative …, 2021 - Elsevier
Peptides are functional active fragments of proteins which can provide nutrients needed for
human growth and development, and they also have unique physiological activity …

Peptide conjugates with small molecules designed to enhance efficacy and safety

R He, B Finan, JP Mayer, RD DiMarchi - Molecules, 2019 - mdpi.com
Peptides constitute molecular diversity with unique molecular mechanisms of action that are
proven indispensable in the management of many human diseases, but of only a mere …

Production, structure–function relationships, mechanisms, and applications of antifreeze peptides

X Chen, J Wu, X Cai, S Wang - Comprehensive Reviews in …, 2021 - Wiley Online Library
Growth of ice crystals can cause serious problems, such as frozen products deterioration,
road damage, energy losses, and safety risks of human beings. Antifreeze peptides (AFPs) …