Sustainability challenges in peptide synthesis and purification: from R&D to production
A Isidro-Llobet, MN Kenworthy… - The Journal of …, 2019 - ACS Publications
In recent years, there has been a growing interest in therapeutic peptides within the
pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 …
pharmaceutical industry with more than 50 peptide drugs on the market, approximately 170 …
Peptide-drug conjugates and their targets in advanced cancer therapies
Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …
standard treatments achieve significant effects in growth inhibition and tumor elimination …
[HTML][HTML] Peptide–drug conjugates (PDCs): a novel trend of research and development on targeted therapy, hype or hope?
C Fu, L Yu, Y Miao, X Liu, Z Yu, M Wei - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Peptide–drug conjugates (PDCs) are the next generation of targeted therapeutics drug after
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …
antibody–drug conjugates (ADCs), with the core benefits of enhanced cellular permeability …
Peptide chemistry toolbox–Transforming natural peptides into peptide therapeutics
M Erak, K Bellmann-Sickert, S Els-Heindl… - Bioorganic & medicinal …, 2018 - Elsevier
The development of solid phase peptide synthesis has released tremendous opportunities
for using synthetic peptides in medicinal applications. In the last decades, peptide …
for using synthetic peptides in medicinal applications. In the last decades, peptide …
Evolving scenario of big data and Artificial Intelligence (AI) in drug discovery
The accumulation of massive data in the plethora of Cheminformatics databases has made
the role of big data and artificial intelligence (AI) indispensable in drug design. This has …
the role of big data and artificial intelligence (AI) indispensable in drug design. This has …
The road to the synthesis of “difficult peptides”
The last decade has witnessed a renaissance of peptides as drugs. This progress, together
with advances in the structural behavior of peptides, has attracted the interest of the …
with advances in the structural behavior of peptides, has attracted the interest of the …
Polysaccharide–peptide conjugates: a versatile material platform for biomedical applications
HQ Song, Y Fan, Y Hu, G Cheng… - Advanced Functional …, 2021 - Wiley Online Library
Natural polymers, such as polysaccharides and proteins, have been widely studied for
numerous biomedical applications because of their bioactivity, natural origin, and …
numerous biomedical applications because of their bioactivity, natural origin, and …
Molecular characteristics and structure–activity relationships of food-derived bioactive peptides
FJ Yang, C Xu, MC Huang, Y Qian, XX Cai… - Journal of Integrative …, 2021 - Elsevier
Peptides are functional active fragments of proteins which can provide nutrients needed for
human growth and development, and they also have unique physiological activity …
human growth and development, and they also have unique physiological activity …
Peptide conjugates with small molecules designed to enhance efficacy and safety
Peptides constitute molecular diversity with unique molecular mechanisms of action that are
proven indispensable in the management of many human diseases, but of only a mere …
proven indispensable in the management of many human diseases, but of only a mere …
Production, structure–function relationships, mechanisms, and applications of antifreeze peptides
X Chen, J Wu, X Cai, S Wang - Comprehensive Reviews in …, 2021 - Wiley Online Library
Growth of ice crystals can cause serious problems, such as frozen products deterioration,
road damage, energy losses, and safety risks of human beings. Antifreeze peptides (AFPs) …
road damage, energy losses, and safety risks of human beings. Antifreeze peptides (AFPs) …