Recent advances in polymeric drug delivery systems

YK Sung, SW Kim - Biomaterials Research, 2020 - spj.science.org
Background Polymeric drug delivery systems have been achieved great development in the
last two decades. Polymeric drug delivery has defined as a formulation or a device that …

[HTML][HTML] Extracellular vesicles as drug delivery systems: Why and how?

OM Elsharkasy, JZ Nordin, DW Hagey… - Advanced drug delivery …, 2020 - Elsevier
Over the past decades, a multitude of synthetic drug delivery systems has been developed
and introduced to the market. However, applications of such systems are limited due to …

Extracellular vesicle heterogeneity and its impact for regenerative medicine applications

SI Van De Wakker, FM Meijers, JPG Sluijter… - Pharmacological …, 2023 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane-enclosed particles that are involved
in physiologic and pathologic processes. EVs are increasingly being studied for therapeutic …

Designer exosomes: a new platform for biotechnology therapeutics

D Jafari, S Shajari, R Jafari, N Mardi, H Gomari, F Ganji… - BioDrugs, 2020 - Springer
Desirable features of exosomes have made them a suitable manipulative platform for
biomedical applications, including targeted drug delivery, gene therapy, cancer diagnosis …

Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy

J Phan, P Kumar, D Hao, K Gao… - Journal of extracellular …, 2018 - Taylor & Francis
Through traditional medicine, there were diseases and disorders that previously remained
untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem …

[HTML][HTML] Exosomes engineering and their roles as therapy delivery tools, therapeutic targets, and biomarkers

N Kučuk, M Primožič, Ž Knez, M Leitgeb - International journal of …, 2021 - mdpi.com
Exosomes are becoming increasingly important therapeutic biomaterials for use in a variety
of therapeutic applications due to their unique characteristics, especially due to the …

Angiogenic Mechanisms of Human CD34+ Stem Cell Exosomes in the Repair of Ischemic Hindlimb

P Mathiyalagan, Y Liang, D Kim, S Misener… - Circulation …, 2017 - ahajournals.org
Rationale: Paracrine secretions seem to mediate therapeutic effects of human CD34+ stem
cells locally transplanted in patients with myocardial and critical limb ischemia and in animal …

Therapeutic effects of transplanted exosomes containing miR-29b to a rat model of Alzheimer's disease

Y Jahangard, H Monfared, A Moradi, M Zare… - Frontiers in …, 2020 - frontiersin.org
Alzheimer disease (AD) is a complex neurodegenerative disorder with no definite treatment.
The expression of miR-29 family is significantly reduced in AD, suggesting a part for the …

Tumor-derived extracellular vesicles: reliable tools for Cancer diagnosis and clinical applications

R Rahbarghazi, N Jabbari, NA Sani, R Asghari… - Cell Communication and …, 2019 - Springer
Background Studies have recently revealed that almost every type of cells including tumor
cells abundantly release small vesicles known as extracellular vesicles (EVs) into the …

Gene therapy for the heart lessons learned and future perspectives

A Cannatà, H Ali, G Sinagra, M Giacca - Circulation research, 2020 - ahajournals.org
While clinical gene therapy celebrates its first successes, with several products already
approved for clinical use and several hundreds in the final stages of the clinical approval …