The traditional two-dimensional (2D) in vitro cell culture system (on a flat support) has long
been used in cancer research. However, this system cannot be fully translated into clinical …

Although classically appreciated for their role as the powerhouse of the cell, the metabolic
functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss how …

Biomolecular and physical cues of the extracellular matrix environment regulate collective
cell dynamics and tissue patterning. Nonetheless, how the viscoelastic properties of the …

There is a need to develop effective therapies for pancreatic ductal adenocarcinoma (PDA),
a highly lethal malignancy with increasing incidence and poor prognosis. Although targeting …

Breast cancer becomes invasive when carcinoma cells invade through the basement
membrane (BM)—a nanoporous layer of matrix that physically separates the primary tumour …

Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …

Background Triple-negative breast cancer (TNBC) is a poor prognostic breast cancer with
the highest mutations and limited therapeutic choices. Cytokine networking between cancer …

Mammalian cells are surrounded by neighbouring cells and extracellular matrix (ECM),
which provide cells with structural support and mechanical cues that influence diverse …

YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and
tumorigenesis. Yet, their function as transcriptional regulators remains underinvestigated. By …

Mechanical cues from the extracellular matrix (ECM) regulate various cellular processes via
distinct mechanotransduction pathways. In breast cancer, increased ECM stiffness promotes …