In the past decade, evidence for the numerous roles of copper (Cu) in mammalian
physiology has grown exponentially. The discoveries of Cu involvement in cell signaling …

Zinc is a crucial trace element in the human body, playing a role in various physiological
processes such as oxidative stress, neurotransmission, protein synthesis, and DNA repair …

Mutations in superoxide dismutase 1 gene (SOD1) are linked to amyotrophic lateral
sclerosis (ALS), a neurodegenerative disorder predominantly affecting upper and lower …

The misfolding and mutation of Cu/Zn superoxide dismutase (SOD1) is commonly
associated with amyotrophic lateral sclerosis (ALS). SOD1 can accumulate within stress …

Coarse-grained modeling has become an important tool to supplement experimental
measurements, allowing access to spatio-temporal scales beyond all-atom based …

Copper is a critical trace element in biological systems due the vast number of essential
enzymes that require the metal as a cofactor, including cytochrome c oxidase, superoxide …

Abstract ALS-causing C71G-hPFN1 coexists in both folded and unfolded states, while
nascent hSOD1 is unfolded. So far, the mechanisms underlying their ALS-triggering …

Protein misfolding and amyloid formation are hallmarks of numerous diseases, including
amyotrophic lateral sclerosis (ALS), in which hSOD1 aggregation is involved in …

Cosmetics and personal care products containing titanium dioxide nanoparticles (TiO 2
NPs) may enter aquatic environments, where the surface coatings of TiO 2 NPs may change …

Galantamine is a natural alkaloid extracted from the Amaryllidaceae plants and is used as
the active ingredient of a drug approved for the treatment of the early stages of Alzheimer's …