Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging …

The demographics of aging suggest a great need for the early diagnosis of dementia and
the development of preventive strategies. Neuropathology and structural MRI studies have …

Every year, millions of brain magnetic resonance imaging (MRI) scans are acquired in
hospitals across the world. These have the potential to revolutionize our understanding of …

Early diagnosis of Alzheimer's disease plays a pivotal role in patient care and clinical trials.
In this study, we have developed a new approach based on 3D deep convolutional neural …

Automated analysis of MRI data of the subregions of the hippocampus requires
computational atlases built at a higher resolution than those that are typically used in current …

We present a technique for automatically assigning a neuroanatomical label to each voxel in
an MRI volume based on probabilistic information automatically estimated from a manually …

Recently, several high dimensional classification methods have been proposed to
automatically discriminate between patients with Alzheimer's disease (AD) or mild cognitive …

Age-related loss of brain tissue has been inferred from cross-sectional neuroimaging
studies, but direct measurements of gray and white matter changes from longitudinal studies …

One of the major neuropathological findings in the brains of individuals with Alzheimer's
disease (AD) is a loss of synaptic contacts in both the neocortex and hippocampus. Here we …

Cerebral blood flow (CBF) velocity is decreased in patients with Alzheimer's disease. It is
being debated whether this reflects diminished demand because of advanced …