Transcription of eukaryotic protein-coding genes commences with the assembly of a
conserved initiation complex, which consists of RNA polymerase II (Pol II) and the general …

DNA repair mechanisms are critical for maintaining the integrity of genomic DNA, and their
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …

The xeroderma pigmentosum protein A (XPA) and replication protein A (RPA) proteins fulfill
essential roles in the assembly of the preincision complex in the nucleotide excision repair …

The versatile nucleotide excision repair (NER) pathway initiates as the XPC–RAD23B–
CETN2 complex first recognizes DNA lesions from the genomic DNA and recruits the …

Nucleotide excision repair is initiated by two different damage recognition subpathways,
global genome repair (GGR) and transcription-coupled repair (TCR). In GGR, XPC detects …

Transcription factor IIH (TFIIH) is a multiprotein complex involved in both eukaryotic
transcription and DNA repair, revealing a tight connection between these two processes …

The XPG/ERCC5 endonuclease was originally identified as the causative gene for
Xeroderma Pigmentosum complementation group G. Ever since its discovery, in depth …

In eukaryotes, three RNA polymerases (RNAPs) play essential roles in the synthesis of
various types of RNA: namely, RNAPI for rRNA; RNAPII for mRNA and most snRNAs; and …

Lack of structure is often an essential functional feature of protein domains. The coordination
of macromolecular assemblies in DNA repair pathways is yet another task disordered …

Anti-ultraviolet (UV) roles of Rad2 and Rad14 depend on nucleotide excision repair (NER)
of UV-induced DNA lesions in budding yeast but remain unexplored yet in filamentous fungi …