MicroRNAs (miRNAs) are endogenous∼ 22 nt RNAs that can play important regulatory
roles in animals and plants by targeting mRNAs for cleavage or translational repression …

MicroRNAs are a family of small, non-coding RNAs that regulate gene expression in a
sequence-specific manner. The two founding members of the microRNA family were …

A conserved biological response to double-stranded RNA, known variously as RNA
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …

Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene
silencing in many organisms by a process known as RNA interference (RNAi). Using a …

Two small temporal RNAs (stRNAs), lin-4 and let-7, control developmental timing in
Caenorhabditis elegans. We find that these two regulatory RNAs are members of a large …

In a diverse group of organisms that includes Caenorhabditis elegans, Drosophila, planaria,
hydra, trypanosomes, fungi and plants, the introduction of double-stranded RNAs inhibits …

Double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA through
a process known as RNA interference (RNAi). Using a recently developed Drosophila in …

MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …

Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced
silencing complex. RISC contains two signature components, small interfering RNAs …

Since the discovery in 1993 of the first small silencing RNA, a dizzying number of small RNA
classes have been identified, including microRNAs (miRNAs), small interfering RNAs …