Synergistic advances in optical physics, probe design, molecular biology, labeling
techniques and computational analysis have propelled fluorescence imaging into new …

Conspectus Biosensors for highly sensitive, selective, and rapid quantification of specific
biomolecules make great contributions to biomedical research, especially molecular …

How cells maintain specific levels of each protein and whether that control is evolutionarily
conserved are key questions. Here, we report proteome-wide steady-state protein turnover …

Chemistry-based protein labeling in living cells is undoubtedly useful for understanding
natural protein functions and for biological/pharmaceutical applications. Here, we report a …

The biologic effects of inorganic arsenic predominantly involve reaction of the trivalent forms
with sulfhydryl groups in critical proteins in target cells, potentially leading to various …

Single-molecule tracking has become a widely used technique for studying protein
dynamics and their organization in the complex environment of the cell. In particular, the …

The covalent attachment of synthetic photoswitches is a general approach to impart light
sensitivity onto native receptors. It mimics the logic of natural photoreceptors and …

Soluble guanylate cyclase (sGC) is responsible for transducing the gaseous signaling
molecule nitric oxide (NO) into the ubiquitous secondary signaling messenger cyclic …

Protein expression levels depend on the balance between their synthesis and degradation
rates. Even quiescent (G0) cells display a continuous turnover of proteins, despite protein …

Assessment of protein dynamics in living cells is crucial for understanding their biological
properties and functions. The SNAP‐tag, a self labeling suicide enzyme, presents a tool with …