Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis
K **, S Wang, Y Zhang, M **a, Y Mo, X Li, G Li… - Cellular and Molecular …, 2019 - Springer
Numerous studies have shown that non-coding RNAs play crucial roles in the development
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …
and progression of various tumor cells. Plasmacytoma variant translocation 1 (PVT1) mainly …
c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
YC Feng, XY Liu, L Teng, Q Ji, Y Wu, JM Li… - Nature …, 2020 - nature.com
The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling
cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal …
cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal …
p53 activates the long noncoding RNA Pvt1b to inhibit Myc and suppress tumorigenesis
The tumor suppressor p53 transcriptionally activates target genes to suppress cellular
proliferation during stress. p53 has also been implicated in the repression of the proto …
proliferation during stress. p53 has also been implicated in the repression of the proto …
LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations
Gene regulatory network perturbations contribute to the development and progression of
cancer, however, molecular determinants that mediate transcriptional perturbations remain a …
cancer, however, molecular determinants that mediate transcriptional perturbations remain a …
Diagnostic and prognostic implications of ribosomal protein transcript expression patterns in human cancers
Background Ribosomes, the organelles responsible for the translation of mRNA, are
comprised of four rRNAs and~ 80 ribosomal proteins (RPs). Although canonically assumed …
comprised of four rRNAs and~ 80 ribosomal proteins (RPs). Although canonically assumed …
A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer
Genetic variation at the 8q24 locus is linked with the greater susceptibility to prostate cancer
in men of African ancestry. One such African ancestry specific rare variant, rs72725854 (A> …
in men of African ancestry. One such African ancestry specific rare variant, rs72725854 (A> …
Natural antisense transcripts: molecular mechanisms and implications in breast cancers
Natural antisense transcripts are RNA sequences that can be transcribed from both DNA
strands at the same locus but in the opposite direction from the gene transcript. Because …
strands at the same locus but in the opposite direction from the gene transcript. Because …
SETD2 Haploinsufficiency Enhances Germinal Center–Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis
SETD2 is the sole histone methyltransferase responsible for H3K36me3, with roles in
splicing, transcription initiation, and DNA damage response. Homozygous disruption of …
splicing, transcription initiation, and DNA damage response. Homozygous disruption of …
Genome-wide screen for differentially methylated long noncoding RNAs identifies Esrp2 and lncRNA Esrp2-as regulated by enhancer DNA methylation with …
The majority of long noncoding RNAs (lncRNAs) is still poorly characterized with respect to
function, interactions with protein-coding genes, and mechanisms that regulate their …
function, interactions with protein-coding genes, and mechanisms that regulate their …