The immunobiology of herpes simplex virus encephalitis and post-viral autoimmunity

J Cleaver, K Jeffery, P Klenerman, M Lim… - Brain, 2024 - academic.oup.com
Herpes simplex virus encephalitis (HSE) is the leading cause of non-epidemic encephalitis
in the developed world and, despite antiviral therapy, mortality and morbidity is high. The …

Cytokines and chemokines: The vital role they play in herpes simplex virus mucosal immunology

JB Smith, JJ Herbert, NR Truong… - Frontiers in …, 2022 - frontiersin.org
Herpes simplex viruses (HSV) types 1 and 2 are ubiquitous infections in humans. They
cause orofacial and genital herpes with occasional severe complications. HSV2 also …

Precise Epitope Organization with Self‐adjuvant Framework Nucleic Acid for Efficient COVID‐19 Peptide Vaccine Construction

F Shen, Z **ong, Y Wu, R Peng, Y Wang… - Angewandte …, 2023 - Wiley Online Library
Peptide vaccines have advantages in easy fabrication and high safety, but their
effectiveness is hampered by the poor immunogenicity of the epitopes themselves. Herein …

Herpes simplex keratitis: A brief clinical overview

M Musa, E Enaholo, G Aluyi-Osa… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
The aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects,
treatment options, management, and current literature available regarding herpes simplex …

Understanding the Interplay between oHSV and the Host Immune System: Implications for Therapeutic Oncolytic Virus Development

K Ayele, H Wakimoto, HJ Nauwynck, HL Kaufman… - Molecular Therapy, 2024 - cell.com
Oncolytic herpes simplex viruses (oHSV) preferentially replicate in cancer cells while
inducing antitumor immunity, and thus, they are often referred to as in situ cancer vaccines …

HSV-1 0∆ NLS vaccine elicits a robust B lymphocyte response and preserves vision without HSV-1 glycoprotein M or thymidine kinase recognition

GB Gmyrek, AN Berube, VH Sjoelund, DJJ Carr - Scientific Reports, 2022 - nature.com
Effective experimental prophylactic vaccines against viral pathogens such as herpes
simplex virus type 1 (HSV-1) have been shown to protect the host through T and/or B …

Validation of ligand tetramers for the detection of antigen-specific lymphocytes

KS Fitzpatrick, HN Degefu, K Poljakov… - The Journal of …, 2023 - journals.aai.org
The study of Ag-specific lymphocytes has been a key advancement in immunology over the
past few decades. The development of multimerized probes containing Ags, peptide: MHC …

[HTML][HTML] Single-cell RNA sequencing reveals the diversity of the immunological landscape response to genital herpes

S Chen, J Zhu, C Hua, C Feng, X Wu, C Zhou, X Chen… - Virologica Sinica, 2024 - Elsevier
Genital herpes (GH) is a common sexually transmitted disease, which is primarily caused by
herpes simplex virus type 2 (HSV-2), and continues to be a global health concern. Although …

Interactions between Herpes Simplex Virus, intraepidermal nerves and epidermal Langerhans and dendritic cells within human skin

JJ Herbert - 2023 - ses.library.usyd.edu.au
Herpes Simplex virus types 1 and 2 (HSV-1 and-2) are prevalent lifelong infections globally,
causing serious complications and predisposing to HIV acquisition. HSV-1 infection of the …

[PDF][PDF] Validation of antigen tetramers for the detection of antigen-specific B cells

KS Fitzpatrick, K Poljakov, MG Bibby, AJ Remington… - researchgate.net
The study of antigen-specific lymphocytes has been a key advancement in immunology over
the past few decades. One innovation allowing for this type of research was the …