[HTML][HTML] Anticancer activities of TCM and their active components against tumor metastasis

K Wang, Q Chen, Y Shao, S Yin, C Liu, Y Liu… - Biomedicine & …, 2021 - Elsevier
Abstract Traditional Chinese Medicine (TCM) has the characteristics of multiple targets,
slight side effects and good therapeutic effects. Good anti-tumor effects are shown by …

Chalcone scaffolds, bioprecursors of flavonoids: Chemistry, bioactivities, and pharmacokinetics

M Rudrapal, J Khan, AAB Dukhyil, RMII Alarousy… - Molecules, 2021 - mdpi.com
Chalcones are secondary metabolites belonging to the flavonoid (C6-C3-C6 system) family
that are ubiquitous in edible and medicinal plants, and they are bioprecursors of plant …

Epidrug repurposing: discovering new faces of old acquaintances in cancer therapy

M Montalvo-Casimiro, R González-Barrios… - Frontiers in …, 2020 - frontiersin.org
Gene mutations are strongly associated with tumor progression and are well known in
cancer development. However, recently discovered epigenetic alterations have shown the …

Targeting epigenetic modifications in Parkinson's disease therapy

D Zhang, J Zhang, Y Wang, G Wang… - Medicinal Research …, 2023 - Wiley Online Library
Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

Anticancer potential of natural chalcones: in vitro and in vivo evidence

R Michalkova, L Mirossay, M Kello… - International Journal of …, 2023 - mdpi.com
There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Garcinol exhibits anti-neoplastic effects by targeting diverse oncogenic factors in tumor cells

V Aggarwal, HS Tuli, J Kaur, D Aggarwal, G Parashar… - Biomedicines, 2020 - mdpi.com
Garcinol, a polyisoprenylated benzophenone, is the medicinal component obtained from
fruits and leaves of Garcinia indica (G. indica) and has traditionally been extensively used …

Molecular mechanisms of antiproliferative effects of natural chalcones

R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …

Garcinol—a natural histone acetyltransferase inhibitor and new anti-cancer epigenetic drug

P Kopytko, K Piotrowska, J Janisiak… - International Journal of …, 2021 - mdpi.com
Garcinol extracted from Garcinia indica fruit peel and leaves is a polyisoprenylated
benzophenone. In traditional medicine it was used for its antioxidant and anti-inflammatory …

Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT-associated phenotypes in mammary organoids

A Chanda, A Sarkar, L Deng, A Bonni, S Bonni - Cell Death & Disease, 2023 - nature.com
Protein post-translational modification by the small ubiquitin-like modifier (SUMO) regulates
the stability, subcellular localization, and interactions of protein substrates with …

Total alkaloid fraction of Leonurus japonicus Houtt. Promotes angiogenesis and wound healing through SRC/MEK/ERK signaling pathway

XQ Shi, G Chen, JQ Tan, Z Li, SM Chen, JH He… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Leonurus japonicus Houtt., also known as
motherwort, is a traditional Chinese medicine that was first identified in Shennong Bencao …