Mode of action-based risk assessment of genotoxic carcinogens

A Hartwig, M Arand, B Epe, S Guth, G Jahnke… - Archives of …, 2020 - Springer
The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

The role of endogenous versus exogenous sources in the exposome of putative genotoxins and consequences for risk assessment

IMCM Rietjens, A Michael, HM Bolt, B Siméon… - Archives of …, 2022 - Springer
The “totality” of the human exposure is conceived to encompass life-associated endogenous
and exogenous aggregate exposures. Process-related contaminants (PRCs) are not only …

Biomonitoring for occupational health risk assessment (BOHRA)

M Manno, C Viau, J Cocker, C Colosio, L Lowry, A Mutti… - Toxicology letters, 2010 - Elsevier
Biological monitoring (BM or biomonitoring) deals with the assessment of individual human
exposure, effect and susceptibility to occupational risk factors. It is a fundamental tool in …

[HTML][HTML] Hemoglobin adducts of acrylamide in human blood–What has been done and what is next?

M Pedersen, E Vryonidis, A Joensen… - Food and Chemical …, 2022 - Elsevier
Acrylamide forms in many commonly consumed foods. In animals, acrylamide causes
tumors, neurotoxicity, developmental and reproductive effects. Acrylamide crosses the …

Mass spectrometry analysis of DNA and protein adducts as biomarkers in human exposure to cigarette smoking: acrolein as an example

HJC Chen - Chemical Research in Toxicology, 2023 - ACS Publications
Acrolein is a major component in cigarette smoke and a product of endogenous lipid
peroxidation. It is difficult to distinguish human exposure to acrolein from exogenous sources …

Analytical approaches for MCPD esters and glycidyl esters in food and biological samples: a review and future perspectives

C Crews, A Chiodini, M Granvogl… - Food Additives & …, 2013 - Taylor & Francis
Esters of 2-and 3-monochloropropane-1, 2-diol (MCPD) and glycidol esters are important
contaminants of processed edible oils used as foods or food ingredients. This review …

[КНИГА][B] Chemical Weapons Convention chemicals analysis: sample collection, preparation and analytical methods

M Mesilaakso - 2005 - books.google.com
Describes the procedures for collection of samples, sample preparation, and analysis of
CWC-related chemicals. It deals with analytical procedures that can be followed in well …

Toward an “omic” physiopathology of reactive chemicals: Thirty years of mass spectrometric study of the protein adducts with endogenous and xenobiotic compounds

FM Rubino, M Pitton, D Di Fabio… - Mass spectrometry …, 2009 - Wiley Online Library
Cancer and degenerative diseases are major causes of morbidity and death, derived from
the permanent modification of key biopolymers such as DNA and regulatory proteins by …

Sex difference in the non-linear relationship between ethylene oxide exposure and depressive symptoms: A cross-sectional study

S Jiang, Y Wang, M Wang, Y Xu, W Zhang… - Journal of Affective …, 2024 - Elsevier
Background Ethylene oxide (EO) has been recognized as an animal carcinogen and
environmental EO exposure was linked to several diseases. However, the association of EO …

New exposure biomarkers as tools for breast cancer epidemiology, biomonitoring, and prevention: a systematic approach based on animal evidence

RA Rudel, JM Ackerman, KR Attfield… - Environmental health …, 2014 - ehp.niehs.nih.gov
Background: Exposure to chemicals that cause rodent mammary gland tumors is common,
but few studies have evaluated potential breast cancer risks of these chemicals in humans …