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Advances in β-cell replacement therapy for the treatment of type 1 diabetes
The main goal of treatment for type 1 diabetes is to control glycaemia with insulin therapy to
reduce disease complications. For some patients, technological approaches to insulin …
reduce disease complications. For some patients, technological approaches to insulin …
Stem cell therapies for treating diabetes: progress and remaining challenges
Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …
diabetes research and therapy. While whole-organ and islet transplantation have become …
Pancreas transplantation
The treatment of patients with diabetes mellitus (DM) presents many challenges to care
providers and represents a major proportion of healthcare expenditure worldwide …
providers and represents a major proportion of healthcare expenditure worldwide …
Transplant strategies for type 1 diabetes: whole pancreas, islet and porcine beta cell therapies
Whole-organ pancreas and islet transplantations are performed in a highly selected group of
patients with diabetes mellitus, primarily those with type 1 diabetes mellitus, complicated by …
patients with diabetes mellitus, primarily those with type 1 diabetes mellitus, complicated by …
A century-long journey from the discovery of insulin to the implantation of stem cell–derived islets
For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …
Advances toward engineering functionally mature human pluripotent stem cell-derived β cells
Human stem cell-derived β (SC-β) cells have the potential to revolutionize diabetes
treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are …
treatment through disease modeling, drug screening, and cellular therapy. SC-β cells are …
[HTML][HTML] Pancreas transplantation: an alarming crisis in confidence
In the past decade, the annual number of pancreas transplantations performed in the United
States has steadily declined. From 2004 to 2011, the overall number of simultaneous …
States has steadily declined. From 2004 to 2011, the overall number of simultaneous …
Pancreas transplantation: current challenges, considerations, and controversies
Pancreas transplantation (PTx) reestablishes an autoregulating source of endogenous
insulin responsive to normal feedback controls. In addition to achieving complete β-cell …
insulin responsive to normal feedback controls. In addition to achieving complete β-cell …
Superior long-term survival for simultaneous pancreas-kidney transplantation as renal replacement therapy: 30-year follow-up of a nationwide cohort
OBJECTIVE In patients with type 1 diabetes and end-stage renal disease, it is controversial
whether a simultaneous pancreas-kidney (SPK) transplantation improves survival compared …
whether a simultaneous pancreas-kidney (SPK) transplantation improves survival compared …
Pancreas and islet transplantation: comparative outcome analysis of a single-centre cohort over 20-years
Objective: To provide the largest single-center analysis of islet (ITx) and pancreas (PTx)
transplantation. Summary Background Data: Studies describing long-term outcomes with ITx …
transplantation. Summary Background Data: Studies describing long-term outcomes with ITx …