Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic
LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge …

Abstract Runt-related transcription factor-1 (RUNX1), also known as acute myeloid
leukaemia 1 protein (AML1), is a member of the core-binding factor family of transcription …

The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …

Cardiac neural crest cells (cNCCs) are a migratory cell population that stem from the cranial
portion of the neural tube. They undergo epithelial-to-mesenchymal transition and migrate …

Rationale: The MSTs (mammalian Ste20-like kinases) 1/2 are members of the HIPPO
pathway that act as growth suppressors in adult proliferative diseases. Pulmonary arterial …

The response of the adult mammalian heart to injury such as myocardial infarction has long
been described as primarily fibrotic scarring and adverse remodeling with little to no …

Abstract Purpose of Review This review provides an overview of the molecular mechanisms
underpinning the cardiac regenerative capacity during the neonatal period and the potential …

Cardiovascular diseases (CVDs) persistently rank as a leading cause of premature death
and illness worldwide. The Hippo signaling pathway, known for its highly conserved nature …

The mortality due to heart diseases remains highest in the world every year, with ischemic
cardiomyopathy being the prime cause. The irreversible loss of cardiomyocytes following …

Myocardial recovery from ischemia-reperfusion (IR) is shaped by the interaction of many
signaling pathways and tissue repair processes, including the innate immune response. We …