Glaucomatous optic neuropathy: Mitochondrial dynamics, dysfunction and protection in retinal ganglion cells
Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …
The role of the ATP-binding cassette A1 (ABCA1) in human disease
Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-
wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide …
wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide …
The vital role for nitric oxide in intraocular pressure homeostasis
Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
Association between diabetes, diabetic retinopathy, and glaucoma
Abstract Purpose of Review The strength of the relationship between diabetes, diabetic
retinopathy (DR), and glaucoma remains controversial. We review evidence supporting and …
retinopathy (DR), and glaucoma remains controversial. We review evidence supporting and …
Molecular genetics of glaucoma: Subtype and ethnicity considerations
Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …
differential presentation as well as ethnic and geographic disparities. The multifactorial …
Update on the genetics of primary open-angle glaucoma
Affecting nearly 80 million individuals, glaucoma is the number one cause of irreversible
blindness in the world. This ocular disease describes a set of optic neuropathies of which …
blindness in the world. This ocular disease describes a set of optic neuropathies of which …
[HTML][HTML] Hyperlipidemia, blood lipid level, and the risk of glaucoma: a meta-analysis
S Wang, X Bao - Investigative ophthalmology & visual science, 2019 - tvst.arvojournals.org
Purpose: Previous studies reported that hyperlipidemia and blood lipid levels were
associated with glaucoma, ocular hypertension (OHT), and intraocular pressure (IOP) …
associated with glaucoma, ocular hypertension (OHT), and intraocular pressure (IOP) …
Clinical implications of recent advances in primary open-angle glaucoma genetics
Over the last decade, genetic studies, including genome-wide association studies (GWAS),
have accelerated the discovery of genes and genomic regions contributing to primary open …
have accelerated the discovery of genes and genomic regions contributing to primary open …
m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer
JX Lin, NZ Lian, YX Gao, QL Zheng, YH Yang… - Cell death & …, 2022 - nature.com
LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its
role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are …
role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are …