The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that
regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural …

More is becoming known about so-called noncanonical Wnt pathways that signal
independently of β-catenin. Here we review recent developments in both the functions and …

Programmable RNA editing enables reversible recoding of RNA information for research
and disease treatment. Previously, we developed a programmable adenosine-to-inosine (A …

O-GlcNAc is a dynamic post-translational modification (PTM) that regulates protein functions.
In studying the regulatory roles of O-GlcNAc, a major roadblock is the inability to change O …

Stroma in the tumor microenvironment plays a critical role in cancer progression, but how it
promotes metastasis is poorly understood. Exosomes are small vesicles secreted by many …

Wnt proteins modulate cell proliferation and differentiation and the self-renewal of stem cells
by inducing β-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the …

MicroRNAs (miRNAs) are critical regulators of gene expression, and exert extensive impacts
on development, physiology, and disease of eukaryotes. A high degree of parallelism is …

The Wnt/β-catenin signaling system plays essential roles in embryonic development and in
the self-renewal and maintenance of adult stem cells. R-spondins (RSPOs) are a group of …

DNA mutations are known cancer drivers. Here we investigated whether mRNA events that
are upregulated in cancer can functionally mimic the outcome of genetic alterations. RNA …

The epithelial-mesenchymal transition (EMT) has been associated with the acquisition of
motility, invasiveness, and self-renewal traits. During both normal development and tumor …