Immune responses to stroke: mechanisms, modulation, and therapeutic potential
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …
Infection as a stroke risk factor and determinant of outcome after stroke
Understanding the relationship between infection and stroke has taken on new urgency in
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …
the era of the coronavirus disease 2019 (COVID-19) pandemic. This association is not a …
Targeting the blood-brain barrier for the delivery of stroke therapies
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …
delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier …
Fantastic IgA plasma cells and where to find them
B Isho, A Florescu, AA Wang… - Immunological …, 2021 - Wiley Online Library
IgA is produced in large quantities at mucosal surfaces by IgA+ plasma cells (PC), protecting
the host from pathogens, and restricting commensal access to the subepithelium. It is …
the host from pathogens, and restricting commensal access to the subepithelium. It is …
Neuronal loss after stroke due to microglial phagocytosis of stressed neurons
GC Brown - International journal of molecular sciences, 2021 - mdpi.com
After stroke, there is a rapid necrosis of all cells in the infarct, followed by a delayed loss of
neurons both in brain areas surrounding the infarct, known as 'selective neuronal loss', and …
neurons both in brain areas surrounding the infarct, known as 'selective neuronal loss', and …
[HTML][HTML] The local and peripheral immune responses to stroke: implications for therapeutic development
The immune response to stroke is an exciting target for future stroke therapies. Stroke is a
leading cause of morbidity and mortality worldwide, and clot removal (mechanical or …
leading cause of morbidity and mortality worldwide, and clot removal (mechanical or …
Role of microglia in stroke
AM Planas - Glia, 2024 - Wiley Online Library
Microglia play key roles in the post‐ischemic inflammatory response and damaged tissue
removal reacting rapidly to the disturbances caused by ischemia and working to restore the …
removal reacting rapidly to the disturbances caused by ischemia and working to restore the …
Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia
MJ Krinock, NS Singhal - Annals of the New York Academy of …, 2021 - Wiley Online Library
Ischemic stroke is a leading cause of morbidity and mortality among type 2 diabetic patients.
Preclinical and translational studies have identified critical pathophysiological mediators of …
Preclinical and translational studies have identified critical pathophysiological mediators of …
Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system
G Hammel, S Zivkovic, M Ayazi, Y Ren - Cellular immunology, 2022 - Elsevier
Central nervous system (CNS) disorders and trauma involving changes to the neuronal
myelin sheath have long been a topic of great interest. One common pathological change in …
myelin sheath have long been a topic of great interest. One common pathological change in …
Increased fatty acid metabolism and decreased glycolysis are hallmarks of metabolic reprogramming within microglia in degenerating white matter during recovery …
SH Loppi, MA Tavera-Garcia… - Journal of Cerebral …, 2023 - journals.sagepub.com
The goal of this study was to evaluate changes in metabolic homeostasis during the first 12
weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. To …
weeks of recovery in a distal middle cerebral artery occlusion mouse model of stroke. To …