Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …

Antiplatelet agents and anticoagulants are a mainstay for the prevention and treatment of
thrombosis. However, despite advances in antithrombotic therapy, a fundamental challenge …

The development of cell membrane-modified biomimetic nanoparticles has extensively
increased during the past years due to their exceptional biocompatibility, evasion from the …

Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …

Beyond platelets function in hemostasis, there is emerging evidence to suggest that platelets
contribute crucially to inflammation and immune responses. Therefore, considering the …

Refractoriness to platelet transfusion is a major problem in a small group of patients, and
large-scale manufacturing of clinical grade functional platelets ex vivo has remained an …

Complete blood count (CBC) is one of the most common blood tests requested by clinicians
and evaluates the total numbers and characteristics of cell components in the blood …

Every day, megakaryocytes produce billions of platelets that circulate for several days and
eventually are cleared by the liver. The exact removal mechanism, however, remains …

Novel platelet and megakaryocyte transcriptome analysis allows prediction of the full or
theoretical proteome of a representative human platelet. Here, we integrated the established …