Biological functions of sphingomyelins
JP Slotte - Progress in lipid research, 2013 - Elsevier
Sphingomyelin (SM) is a dominant sphingolipid in membranes of mammalian cells and this
lipid class is specifically enriched in the plasma membrane, the endocytic recycling …
lipid class is specifically enriched in the plasma membrane, the endocytic recycling …
[HTML][HTML] Pore formation by actinoporins, cytolysins from sea anemones
Actinoporins (APs) from sea anemones are~ 20 kDa pore forming toxins with a β-sandwich
structure flanked by two α-helices. The molecular mechanism of APs pore formation is …
structure flanked by two α-helices. The molecular mechanism of APs pore formation is …
Structural basis for self-assembly of a cytolytic pore lined by protein and lipid
K Tanaka, JMM Caaveiro, K Morante… - Nature …, 2015 - nature.com
Pore-forming toxins (PFT) are water-soluble proteins that possess the remarkable ability to
self-assemble on the membrane of target cells, where they form pores causing cell damage …
self-assemble on the membrane of target cells, where they form pores causing cell damage …
A common toxin fold mediates microbial attack and plant defense
C Ottmann, B Luberacki, I Küfner… - Proceedings of the …, 2009 - National Acad Sciences
Many plant pathogens secrete toxins that enhance microbial virulence by killing host cells.
Usually, these toxins are produced by particular microbial taxa, such as bacteria or fungi. In …
Usually, these toxins are produced by particular microbial taxa, such as bacteria or fungi. In …
The rise and fall of an evolutionary innovation: contrasting strategies of venom evolution in ancient and young animals
Animal venoms are theorized to evolve under the significant influence of positive Darwinian
selection in a chemical arms race scenario, where the evolution of venom resistance in prey …
selection in a chemical arms race scenario, where the evolution of venom resistance in prey …
[HTML][HTML] Pore formation: an ancient yet complex form of attack
I Iacovache, FG van der Goot, L Pernot - Biochimica et Biophysica Acta …, 2008 - Elsevier
Bacteria, as well as higher organisms such as sea anemones or earthworms, have
developed sophisticated virulence factors such as the pore-forming toxins (PFTs) to mount …
developed sophisticated virulence factors such as the pore-forming toxins (PFTs) to mount …
Molecular mechanism of pore formation by actinoporins
Actinoporins are effective pore-forming toxins produced by sea anemones. These extremely
potent, basic 20kDa proteins readily form pores in membranes that contain sphingomyelin …
potent, basic 20kDa proteins readily form pores in membranes that contain sphingomyelin …
Evolution of an ancient venom: recognition of a novel family of cnidarian toxins and the common evolutionary origin of sodium and potassium neurotoxins in sea …
M Jouiaei, K Sunagar… - Molecular biology …, 2015 - academic.oup.com
Despite Cnidaria (sea anemones, corals, jellyfish, and hydroids) being the oldest venomous
animal lineage, structure–function relationships, phyletic distributions, and the molecular …
animal lineage, structure–function relationships, phyletic distributions, and the molecular …
[HTML][HTML] Sticholysins, two pore-forming toxins produced by the Caribbean Sea anemone Stichodactyla helianthus: their interaction with membranes
Sticholysins (Sts) I and II (StI/II) are pore-forming toxins (PFTs) produced by the Caribbean
Sea anemone Stichodactyla helianthus belonging to the actinoporin family, a unique class …
Sea anemone Stichodactyla helianthus belonging to the actinoporin family, a unique class …
Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins
Pore-forming toxins (PFTs) are proteins that are secreted as soluble molecules and are
inserted into membranes to form oligomeric transmembrane pores. In this paper, we report …
inserted into membranes to form oligomeric transmembrane pores. In this paper, we report …