Contemporary approaches for amide bond formation

P Acosta‐Guzmán, A Ojeda‐Porras… - Advanced Synthesis …, 2023 - Wiley Online Library
Amide bond construction has garnered significant interest in recent decades due to amides
being one of the most prevalent functional groups among bioactive molecules. Out of the …

Cyrene: a bio-based novel and sustainable solvent for organic synthesis

NA Stini, PL Gkizis, CG Kokotos - Green Chemistry, 2022 - pubs.rsc.org
Dihydrolevoclucosenone (Cyrene is its market name) is a biomass-derived solvent that can
be produced in only two steps from biomass, while being biodegradable, non-mutagenic …

Biocatalytic amide bond formation

M Lubberink, W Finnigan, SL Flitsch - Green Chemistry, 2023 - pubs.rsc.org
Amide bonds occur in over half of target compounds in medicinal chemistry patents, making
amide bond formation the most commonly performed reaction in the pharmaceutical …

Role and recent advancements of ionic liquids in drug delivery systems

MK Shukla, H Tiwari, R Verma, WL Dong, S Azizov… - Pharmaceutics, 2023 - mdpi.com
Advancements in the fields of ionic liquids (ILs) broaden its applications not only in
traditional use but also in different pharmaceutical and biomedical fields. Ionic liquids …

Water: an underestimated solvent for amide bond-forming reactions

S Hazra, F Gallou, S Handa - ACS Sustainable Chemistry & …, 2022 - ACS Publications
Construction of the amide/peptide bond is one of the most encountered transformations in
the pharmaceutical and chemical industries. Traditional protocols rely on the use of …

Cyrene: a bio-based solvent for the Mizoroki–Heck reaction of aryl iodides

NA Stini, PL Gkizis, CG Kokotos - Organic & biomolecular chemistry, 2023 - pubs.rsc.org
The development of greener and more sustainable methods, as well as the adaptation of
already existing protocols to more environmentally friendly procedures, has become crucial …

[HTML][HTML] Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for Cancer Therapy: Advances, Challenges, and Future Directions

D Bondar, Y Karpichev - Biomolecules, 2024 - mdpi.com
Poly (ADP-ribose) polymerases (PARPs) are crucial nuclear proteins that play important
roles in various cellular processes, including DNA repair, gene transcription, and cell death …

Sustainable valorisation of renewables through dialkyl carbonates and isopropenyl esters

G Fiorani, A Perosa, M Selva - Green Chemistry, 2023 - pubs.rsc.org
This review showcases a thorough analysis of reactions and applications of the most
widespread linear and alkylene organic carbonates (DACs), dimethyl-, diethyl-, ethylene …

Reactive deep eutectic solvents for EDC-mediated amide synthesis

D Procopio, C Siciliano, ML Di Gioia - Organic & Biomolecular …, 2024 - pubs.rsc.org
The sustainability of amide bond formation is an ever-present topic in the pharmaceutical
industry, as it represents the common motif in many clinically approved drugs. Despite many …

Perspectives from the 2022 Cohort of the American Chemical Society Summer School on Green Chemistry & Sustainable Energy

M Saraf, MA Roy, F Yarur Villanueva… - ACS Sustainable …, 2023 - ACS Publications
The field of chemistry is uniquely equipped to solve many current and impending global
challenges; however, minimizing potential negative impacts on the environment, society …