Observations into quantum simulation, spectroscopy, electronic properties, pharmacokinetics and molecular docking analysis of lawsone against breast cancer

K Chandran, A Zochedh, AB Sultan… - Journal of Molecular …, 2023 - Elsevier
In this current investigation, structural and spectroscopic characteristics of the Lawsone (2-
hydroxy-1, 4-napthoquinone) molecule was examined by density functional theory (DFT) …

Exploring the co‐activity of FDA approved drug gemcitabine and docetaxel for enhanced anti‐breast cancer activity: DFT, docking, molecular dynamics simulation and …

S Sukumaran, A Zochedh, K Chandran… - … Journal of Quantum …, 2024 - Wiley Online Library
Combining FDA‐approved medications may increase biological activity by simultaneously
targeting many protein mechanisms while being less toxic. Gemcitabine and docetaxel …

Pharmacoinformatics and quantum chemicals‐based analysis of aromatic molecule decanal as a potent drug against breast cancer

K Arumugam, K Chandran, A Zochedh… - … Journal of Quantum …, 2024 - Wiley Online Library
This study's primary goal is to perform density functional theory and molecular docking
simulation to determine decanal's structural stability and biological activity against proteins …

Synthesis of 1-piperoylpiperidine investigated through spectroscopy, quantum computation, pharmaceutical activity, docking and MD simulation against breast cancer

K Chandran, A Zochedh, AB Sultan… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Piperoylpiperidine (1-PIP) was crystallized as a single unit by a slow evaporation process,
and it was examined using XRD and FT-IR spectroscopy. The centrosymmetric monoclinic …

Investigation on 5-Isopropyl-2-Methylphenol via Quantum Chemicals, pharmacokinetics, molecular docking and cytotoxicity evaluation against breast Cancer

K Chandran, A Zochedh, AB Sultan… - Journal of …, 2024 - World Scientific
The 5-isopropyl-2-methylphenol (5IP2MP) molecule, a monoterpenoid phenol mostly
existing in the essential oil of Origanum vulgare L., was used as a potent breast cancer …

Encapsulating 2-aminopyridine with zeolite imidazole framework nanoparticles for induction of cell death via pH-responsive delivery in hepatocellular carcinoma …

A Zochedh, K Chandran, K Arumugam… - Polycyclic Aromatic …, 2024 - Taylor & Francis
The key objective for establishing a new drug delivery system is to transport therapeutic
medications in the body's circulatory system and deliver them to selected therapeutic spots …

Combined experimental and quantum computational studies on 5-Fluorouracil salicylic acid cocrystal: Assessment on anti-breast cancer potential through docking …

J Karuppasamy, A Zochedh, BA Al-Asbahi… - Journal of Molecular …, 2024 - Elsevier
fluorouracil salicylic acid (5FUSA) cocrystal was synthesised via mechanochemical and
solution evaporation technique and spectroscopic experiments and theoretical research …

Integrating simulated and experimental studies on novel single crystal bis (guanidininium) n-carboxylatephenylalanine towards enhanced antitumor effect

A Zochedh, A Shunmuganarayanan, S Ansar… - Journal of Molecular …, 2025 - Elsevier
A novel organic crystal bis (guanidininium) n-carboxylatephenylalanine (GUPA) was
synthesized and X-ray diffraction outcomes exposed P2 1, triclinic space group with cell …

Exploring the synergistic effect of tegafur-syringic acid adduct against breast cancer through DFT computation, spectroscopy, pharmacokinetics and molecular docking …

A Zochedh, K Chandran… - Polycyclic Aromatic …, 2024 - Taylor & Francis
The most prevalent kind of cancer and the main reason for cancer-related deaths in women
is breast cancer. Synergistic drug delivery plays an effective role in the treatment of cancer …

Solid state synthesis of zwitterionic cocrystal 5-fluorouracil L-phenylalanine explicated via structural, spectroscopy, quantum chemicals, Hirshfeld and docking analysis

J Karuppasamy, A Zochedh… - Journal of Molecular …, 2024 - Elsevier
The single crystal 5-Fluorouracil l-phenylalanine (5FUPA) was synthesized using solid state
technique and crystallized at room temperature using the slow evaporation method. The …