Clinical implications of T cell exhaustion for cancer immunotherapy
Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …
CD8+ T cell states in human cancer: insights from single-cell analysis
AM Van der Leun, DS Thommen… - Nature Reviews …, 2020 - nature.com
The T cell infiltrates that are formed in human cancers are a modifier of natural disease
progression and also determine the probability of clinical response to cancer …
progression and also determine the probability of clinical response to cancer …
Determining cell type abundance and expression from bulk tissues with digital cytometry
Single-cell RNA-sequencing has emerged as a powerful technique for characterizing
cellular heterogeneity, but it is currently impractical on large sample cohorts and cannot be …
cellular heterogeneity, but it is currently impractical on large sample cohorts and cannot be …
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
T cell dysfunction is a hallmark of many cancers, but the basis for T cell dysfunction and the
mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) …
mechanisms by which antibody blockade of the inhibitory receptor PD-1 (anti-PD-1) …
Temporal single-cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer
Anti-PD-1 treatment has shown unprecedented clinical success in the treatment of non-small-
cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood …
cell lung cancer (NSCLC), but the underlying mechanisms remain incompletely understood …
Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade
Immune-checkpoint blockade (ICB) therapies represent a paradigm shift in the treatment of
human cancers; however, it remains incompletely understood how tumor-reactive T cells …
human cancers; however, it remains incompletely understood how tumor-reactive T cells …
Intratumoral Tcf1+ PD-1+ CD8+ T cells with stem-like properties promote tumor control in response to vaccination and checkpoint blockade immunotherapy
I Siddiqui, K Schaeuble, V Chennupati, SAF Marraco… - Immunity, 2019 - cell.com
Checkpoint blockade mediates a proliferative response of tumor-infiltrating CD8+ T
lymphocytes (TILs). The origin of this response has remained elusive because chronic …
lymphocytes (TILs). The origin of this response has remained elusive because chronic …
Metabolic competition in the tumor microenvironment is a driver of cancer progression
Failure of T cells to protect against cancer is thought to result from lack of antigen
recognition, chronic activation, and/or suppression by other cells. Using a mouse sarcoma …
recognition, chronic activation, and/or suppression by other cells. Using a mouse sarcoma …
Anti-PD-1 and anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations
Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …
Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving
to be effective at restoring T cell-mediated immune responses that can lead to marked and …
to be effective at restoring T cell-mediated immune responses that can lead to marked and …