Dopamine regulates reward-related behavior through the mesolimbic dopaminergic
pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the …

Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Chronic stress can have lasting adverse consequences in some individuals, yet others are
resilient to the same stressor,. Susceptible and resilient individuals exhibit differences in the …

Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …

Mood disorders are common and debilitating conditions characterized in part by profound
deficits in reward-related behavioural domains. A recent literature has identified important …

Stress often affects our social lives. When undergoing high-level or persistent stress,
individuals frequently retract from social interactions and become irritable and hostile …

Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …

Enhanced glutamatergic transmission in the nucleus accumbens (NAc), a region critical for
reward and motivation, has been implicated in the pathophysiology of depression; however …

The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional,
motivational, and social reward associations together with their more demanding cognitive …

Ventral tegmental area (VTA) dopamine neurons in the brain's reward circuit have a crucial
role in mediating stress responses,,,, including determining susceptibility versus resilience to …