Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

One of the most striking hallmarks shared by various neurodegenerative diseases, including
Parkinson's disease, Alzheimer's disease (AD), and amyotrophic lateral sclerosis, is …

Here we have identified a surface protein, TIGIT, containing an immunoglobulin variable
domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif …

The immune response in the brain has been widely investigated and while many studies
have focused on the proinflammatory cytotoxic response, the brain's innate immune system …

Food processing can have many beneficial effects. However, processing may also alter the
allergenic properties of food proteins. A wide variety of processing methods is available and …

Clinical and epidemiologic studies have suggested an association between infectious
agents and chronic inflammatory disorders and cancer. Better understanding of microbial …

Biglycan, a small leucine-rich proteoglycan, is a ubiquitous ECM component; however, its
biological role has not been elucidated in detail. Here we show that biglycan acts in …

Myeloid cells are key drivers of physiological responses to pathogen invasion or tissue
damage. Members of the C-type lectin receptor (CLR) family stand out among the …

Mycobacterium tuberculosis (M. tb) survives in macrophages in part by limiting phagosome–
lysosome (PL) fusion. M. tb mannose-capped lipoarabinomannan (ManLAM) blocks …

Tuberculosis (TB) remains one of the greatest threats to human health. The causative
bacterium, Mycobacterium tuberculosis (Mtb), is acquired by the respiratory route. It is …