Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for
smoking cessation, a potential medication for several diseases, and a useful probe drug for …

Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …

Flavonoids-a class of low molecular weight secondary metabolites-are ubiquitous and
cornucopia throughout the plant kingdom. Structurally, the main structure consists of C6-C3 …

This review aims to provide an extensive overview of the literature on the clinical
pharmacokinetics of mycophenolate in solid organ transplantation and a briefer summary of …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

Purpose To determine whether uridine diphosphate-glucuronosyltransferase 1A1, UGT1A7,
and UGT1A9 polymorphisms affect the pharmacokinetics (PK) of irinotecan and treatment …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

Purpose: Capecitabine and irinotecan are commonly used in the treatment of metastatic
colorectal cancer (CRC). We hypothesized that germline polymorphisms within genes …

Uridine-disphosphate glucuronosyl transferase (UGT) enzymes catalyze the formation of
glucuronide conjugates of phase II metabolism. Methods for absolute quantification of …

The anticancer agent irinotecan (CPT-11) is converted to SN-38, which is approximately 100
to 1000-fold more cytotoxic than the parent drug. The pharmacokinetics of irinotecan are …