Omics approaches for the assessment of biological responses to nanoparticles

Y Abdelkader, L Perez-Davalos, R LeDuc… - Advanced Drug Delivery …, 2023 - Elsevier
Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …

Targeted liquid chromatography‐tandem mass spectrometry analysis of proteins: Basic principles, applications, and perspectives

A Kulyyassov, M Fresnais, R Longuespée - Proteomics, 2021 - Wiley Online Library
Liquid chromatography coupled to tandem mass spectrometry (LC‐MS/MS) is now the main
analytical method for the identification and quantification of peptides and proteins in …

An inflection point in high-throughput proteomics with Orbitrap Astral: analysis of biofluids, cells, and tissues

NG Hendricks, SD Bhosale, AJ Keoseyan… - Journal of Proteome …, 2024 - ACS Publications
This Technical Note presents a comprehensive proteomics workflow for the new
combination of Orbitrap and Astral mass analyzers across biofluids, cells, and tissues …

Proteomics in the pharmaceutical and biotechnology industry: a look to the next decade

JR Lill, WR Mathews, CM Rose… - Expert Review of …, 2021 - Taylor & Francis
Introduction Pioneering technologies such as proteomics have helped fuel the
biotechnology and pharmaceutical industry with the discovery of novel targets and an …

A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study

Z Wang, A Cryar, O Lemke, P Tober-Lau… - …, 2022 - thelancet.com
Background Global healthcare systems continue to be challenged by the COVID-19
pandemic, and there is a need for clinical assays that can help optimise resource allocation …

[HTML][HTML] Mass spectrometry-based proteomic technology and its application to study skeletal muscle cell biology

P Dowling, D Swandulla, K Ohlendieck - Cells, 2023 - mdpi.com
Voluntary striated muscles are characterized by a highly complex and dynamic proteome
that efficiently adapts to changed physiological demands or alters considerably during …

Assessment of a 60-biomarker health surveillance panel (HSP) on whole blood from remote sampling devices by targeted LC/MRM-MS and discovery DIA-MS …

SA Whelan, N Hendricks, ZL Dwight, Q Fu… - Analytical …, 2023 - ACS Publications
Telehealth, accessing healthcare and wellness remotely, should be a cost-effective and
efficient way for individuals to receive care. The convenience of having a reliable remote …

[HTML][HTML] Quantitative Proteomics of Maternal Blood Plasma in Isolated Intrauterine Growth Restriction

NL Starodubtseva, AO Tokareva… - International Journal of …, 2023 - mdpi.com
Intrauterine growth restriction (IUGR) remains a significant concern in modern obstetrics,
linked to high neonatal health problems and even death, as well as childhood disability …

Typic: A Practical and Robust Tool to Rank Proteotypic Peptides for Targeted Proteomics

BA Pauletti, DC Granato, C M. Carnielli… - Journal of Proteome …, 2022 - ACS Publications
The selection of a suitable proteotypic peptide remains a challenge for designing a targeted
quantitative proteomics assay. Although the criteria are well-established in the literature, the …

[HTML][HTML] Targeted proteomics for evaluating risk of venous thrombosis following traumatic lower‐leg injury or knee arthroscopy

Y Mohammed, CE Touw, B Nemeth… - Journal of Thrombosis …, 2022 - Elsevier
Introduction Patients with lower‐leg cast immobilization and patients undergoing knee
arthroscopy have an increased risk of venous thrombosis (VT). Guidelines are ambiguous …