Minor histocompatibility antigens: past, present, and future

E Spierings - Tissue Antigens, 2014 - Wiley Online Library
Minor histocompatibility (H) antigens are key molecules driving allo‐immune responses in
both graft‐versus‐host‐disease (GvHD) and in graft‐versus‐leukemia (GvL) reactivity in …

Autosomal minor histocompatibility antigens: how genetic variants create diversity in immune targets

M Griffioen, CAM van Bergen… - Frontiers in …, 2016 - frontiersin.org
Allogeneic stem cell transplantation (alloSCT) can be a curative treatment for hematological
malignancies. Unfortunately, the desired anti-tumor or graft-versus-leukemia (GvL) effect is …

Exploiting T cells specific for human minor histocompatibility antigens for therapy of leukemia

M Bleakley, SR Riddell - Immunology and cell biology, 2011 - Wiley Online Library
Minor histocompatibility (H) antigens are major targets of a graft‐versus‐leukemia (GVL)
effect mediated by donor CD8+ and CD4+ T cells following allogeneic hematopoietic cell …

Transplant genetics and genomics

JYC Yang, MM Sarwal - Nature Reviews Genetics, 2017 - nature.com
Ever since the discovery of the major histocompatibility complex, scientific and clinical
understanding in the field of transplantation has been advanced through genetic and …

TCR-like CAR-T cells targeting MHC-bound minor histocompatibility antigens

Y Akatsuka - Frontiers in Immunology, 2020 - frontiersin.org
Minor histocompatibility antigens (mHAgs) in allogeneic hematopoietic stem cell
transplantation are highly immunogenic as they are foreign antigens and cause …

Minor histocompatibility antigen-specific T cells

C Summers, VS Sheth, M Bleakley - Frontiers in Pediatrics, 2020 - frontiersin.org
Minor Histocompatibility (H) antigens are major histocompatibility complex (MHC)/Human
Leukocyte Antigen (HLA)-bound peptides that differ between allogeneic hematopoietic stem …

High-throughput characterization of 10 new minor histocompatibility antigens by whole genome association scanning

CAM Van Bergen, CE Rutten, ED Van Der Meijden… - Cancer research, 2010 - AACR
Patients with malignant diseases can be effectively treated with allogeneic hematopoietic
stem cell transplantation (allo-SCT). Polymorphic peptides presented in HLA molecules, the …

An unexplored angle: T cell antigen discoveries reveal a marginal contribution of proteasome splicing to the immunogenic MHC class I antigen pool

T Verkerk, SJI Koomen, KJ Fuchs… - Proceedings of the …, 2022 - National Acad Sciences
In the current era of T cell–based immunotherapies, it is crucial to understand which types of
MHC-presented T cell antigens are produced by tumor cells. In addition to linear peptide …

Expanding the repertoire reveals recurrent, cryptic, and hematopoietic HLA class I minor histocompatibility antigens

KJ Fuchs, M van de Meent, MW Honders, I Khatri… - Blood, 2024 - ashpublications.org
Allogeneic stem cell transplantation (alloSCT) is a curative treatment for hematological
malignancies. After HLA-matched alloSCT, antitumor immunity is caused by donor T cells …

Identification of 4 new HLA-DR–restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity

AN Stumpf, ED van der Meijden… - Blood, The Journal …, 2009 - ashpublications.org
Potent graft-versus-leukemia (GVL) effects can be mediated by donor-derived T cells
recognizing minor histocompatibility antigens (mHags) in patients treated with donor …