BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

A hallmark of metastasis is the adaptation of tumor cells to new environments. Metabolic
constraints imposed by the serine and glycine–limited brain environment restrict metastatic …

Brain metastases (BMs) frequently occur in primary tumors such as lung cancer, breast
cancer, and melanoma, and are associated with notably short natural survival. In addition to …

Abstract Di-2-pyridylketone-4, 4,-dimethyl-3-thiosemicarbazone (Dp44mT) is being
developed as an iron chelator with selective anticancer activity. We investigated the …

Anthracycline-induced cardiomyopathy is a major problem in anti-cancer therapy. The only
approved agent for alleviating this serious dose limiting side effect is ICRF-187 …

Background and Purpose The catalytic topoisomerase II inhibitor dexrazoxane has been
associated not only with improved cancer patient survival but also with secondary …

Emerging evidence has demonstrated that the integrity and the function of blood-brain
barrier (BBB) are gradually impaired in the processes of aging and nervous system …

Photodynamic therapy (PDT) utilizes the combined interaction of a photosensitizer, light and
molecular oxygen to ablate tumor tissue. Maximizing the accumulation of the photosensitizer …

The intention of the present study was to answer the question whether the catalytic
topoisomerase-II inhibitor, dexrazoxane, can be used as a modulator of teniposide-induced …

Background: Chondrosarcomas and chordomas are reported to have low radio-sensitivity.
Therefore, a study was undertaken to explore the radioresponsiveness of these tumours …