Amyotrophic lateral sclerosis represents corticomotoneuronal system failure

A Eisen, S Vucic, MC Kiernan - Muscle & Nerve, 2024 - Wiley Online Library
Several decades have passed since the anterograde corticomotoneuronal hypothesis for
amyotrophic lateral sclerosis (ALS) was proposed. The intervening years have witnessed its …

Liquid–liquid phase separation of Tau and α-synuclein: a new target for treating comorbidity in neurodegeneration

NN Foressi, LC Rodríguez, MS Celej - Biophysical Reviews, 2024 - Springer
Alzheimer's and Parkinson's diseases are the most common neurodegenerative disorders,
causing significant disability and mortality worldwide. Though traditionally classified as Tau …

Development and analysis of silver-iron nitroprusside nanoparticles incorporated into starch-xanthan gum films for extending blueberry shelf life

L Zhang, A Sathiyaseelan, X Zhang, Y Lu… - Progress in Organic …, 2025 - Elsevier
Given the increasing health risks and environmental pollution caused by non-degradable
petroleum-based packaging materials, develo** environmentally friendly packaging …

Chaperone-Mediated Heterotypic Phase Separation Prevents the Amyloid Formation of the Pathological Y145Stop Prion Protein Variant

L Arora, D Bhowmik, S Sarkar, A Sarbahi… - Journal of Molecular …, 2025 - Elsevier
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
crucial for the spatiotemporal regulation of a diverse array of essential cellular functions and …

Thermal aggregation of immunoglobulin G depending on the charge state of protein–polyelectrolyte complexes

A Nomoto, K Shiraki - International Journal of Biological Macromolecules, 2025 - Elsevier
Protein–polyelectrolyte complexes (PPCs) exhibit opposite effects, both suppressing and
promoting protein aggregation, depending on the type of components. For the application of …

Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure

D Scholl, T Boyd, AP Latham, A Salazar, A Khan… - bioRxiv, 2024 - biorxiv.org
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular
processes. Yet, the relationship between atomic features and condensate function remains …

Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates

E Zippo, D Dormann, T Speck, LS Stelzl - bioRxiv, 2024 - biorxiv.org
Understanding the condensation and aggregation of intrinsically disordered proteins in a
non-equilibrium environment is crucial for unraveling many biological processes. Active …

Biomolecular Condensates can Induce Local Membrane Potentials

A Gurunian, K Lasker, AA Deniz - bioRxiv, 2024 - biorxiv.org
Biomolecular condensates are a ubiquitous component of cells, known for their ability to
selectively partition and compartmentalize biomolecules without the need for a lipid …

Physics of droplet regulation in biological cells

D Zwicker, OW Paulin, C ter Burg - arxiv preprint arxiv:2501.13639, 2025 - arxiv.org
Droplet formation has emerged as an essential concept for the spatiotemporal organisation
of biomolecules in cells. However, classical descriptions of droplet dynamics based on …

Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion protein

L Arora, D Bhowmik, S Sarkar, A Sarbahi, SK Rai… - bioRxiv, 2024 - biorxiv.org
Biomolecular condensates formed via phase separation of proteins and nucleic acids are
crucial for the spatiotemporal regulation of a diverse array of essential cellular functions and …