Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

The tumor microenvironment (TME) profoundly influences tumorigenesis, with gene
expression in the breast TME capable of predicting clinical outcomes. The TME is complex …

Chronic damage following oncogene induction or cancer therapy can produce cellular
senescence. Senescent cells not only exit the cell cycle but communicate damage signals to …

MALAT1, one of the few highly conserved nuclear long noncoding RNAs (lncRNAs), is
abundantly expressed in normal tissues. Previously, targeted inactivation and genetic …

Colorectal cancer (CRC) constitutes the second leading cause of cancer-related death
worldwide and advanced CRCs are resistant to targeted therapies, chemotherapies and …

Abstract Gram-negative (G−) microflora dysbiosis occurs in multiple digestive tumors and is
found to be the dominant microflora in the esophageal squamous cell carcinoma (ESCC) …

Aging and cancer are increasingly becoming big challenges for public health worldwide due
to increased human life expectancy. Meanwhile, aging is one of the major risk factors for …

Mesenchymal-epithelial plasticity driving cancer progression in cancer-associated
fibroblasts (CAFs) is undetermined. This work identifies a subgroup of CAFs in human breast …

Patients with tumors that do not respond to immune-checkpoint inhibition often harbor a non-
T cell-inflamed tumor microenvironment, characterized by the absence of IFN-γ-associated …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by uniquely desmoplastic
stroma and chronic inflammatory milieu and has posed a major therapeutic challenge due to …