[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions

L Statello, CJ Guo, LL Chen, M Huarte - Nature reviews Molecular cell …, 2021 - nature.com
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

Non-coding RNA in cancer

H Yan, P Bu - Essays in biochemistry, 2021 - portlandpress.com
Majority of the human genome is transcribed to RNAs that do not encode proteins. These
non-coding RNAs (ncRNAs) play crucial roles in regulating the initiation and progression of …

The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

[HTML][HTML] Oncogenic signaling pathways in the cancer genome atlas

F Sanchez-Vega, M Mina, J Armenia, WK Chatila… - Cell, 2018 - cell.com
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co …

[HTML][HTML] Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis

Y Feng, M Spezia, S Huang, C Yuan, Z Zeng, L Zhang… - Genes & diseases, 2018 - Elsevier
As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

Tumor immune microenvironment lncRNAs

EG Park, SJ Pyo, Y Cui, SH Yoon… - Briefings in …, 2022 - academic.oup.com
Long non-coding ribonucleic acids (RNAs)(lncRNAs) are key players in tumorigenesis and
immune responses. The nature of their cell type-specific gene expression and other …

Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and …

ZQ Zheng, ZX Li, GQ Zhou, L Lin, LL Zhang, JW Lv… - Cancer research, 2019 - AACR
Long noncoding RNAs (lncRNA) play important roles in the tumorigenesis and progression
of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms …

DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression

Y Gu, S Niu, Y Wang, L Duan, Y Pan, Z Tong, X Zhang… - Cancer research, 2021 - AACR
Abstract Aberrant N 6-methyladenosine (m6A) modification has emerged as a driver of
tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the …

DNA-methylation-mediated activating of lncRNA SNHG12 promotes temozolomide resistance in glioblastoma

C Lu, Y Wei, X Wang, Z Zhang, J Yin, W Li, L Chen… - Molecular cancer, 2020 - Springer
Background Accumulating evidence shows that long noncoding RNAs (lncRNAs) are
important regulator molecules involved in diverse biological processes. Acquired drug …

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

S Zhu, JZ Wang, D Chen, YT He, N Meng… - Nature …, 2020 - nature.com
Abstract N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic RNAs.
The biological importance of m6A relies on m6A readers, which control mRNA fate and …