Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium)-induced hepatotoxicity–A review

K Renu, R Chakraborty, H Myakala, R Koti… - Chemosphere, 2021 - Elsevier
Heavy metals pose a serious threat if they go beyond permissible limits in our bodies. Much
heavy metal's viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious …

Mitochondria as the target of hepatotoxicity and drug-induced liver injury: molecular mechanisms and detection methods

M Mihajlovic, M Vinken - International journal of molecular sciences, 2022 - mdpi.com
One of the major mechanisms of drug-induced liver injury includes mitochondrial
perturbation and dysfunction. This is not a surprise, given that mitochondria are essential …

Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury

F Lin, W Chen, J Zhou, J Zhu, Q Yao, B Feng… - Cell death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) have attracted interest for their potential to alleviate liver
injury. Here, the protective effect of MSCs on carbon tetrachloride (CCl4)-induced acute liver …

Hepatoprotective Effect of Apigenin Against Liver Injury via the Non-canonical NF-κB Pathway In Vivo and In Vitro

S Yue, N Xue, H Li, B Huang, Z Chen, X Wang - Inflammation, 2020 - Springer
Apigenin, a flavonoid found in many plants, has various biological properties. We aimed to
investigate the anti-inflammatory and anti-oxidative activity of apigenin against carbon …

Docetaxel and lidocaine co-loaded (NLC-in-hydrogel) hybrid system designed for the treatment of melanoma

LD de Moura, LNM Ribeiro, FV de Carvalho… - Pharmaceutics, 2021 - mdpi.com
Melanoma is the most aggressive skin carcinoma and nanotechnology can bring new
options for its pharmacological treatment. Nanostructured lipid carriers (NLC) are ideal drug …

Binary polymeric amorphous carvedilol solid dispersions: In vitro and in vivo characterization

M Krstić, L Manić, N Martić, D Vasiljević… - European Journal of …, 2020 - Elsevier
Binary polymeric amorphous carvedilol solid dispersions were prepared using solvent
method by varying solvent type, polymer type and carvedilol to polymer ratio in order to …

Antioxidative and protective actions of apigenin in a paracetamol-induced hepatotoxicity rat model

A Rašković, S Gigov, I Čapo, M Paut Kusturica… - European Journal of …, 2017 - Springer
Abstract Background and Objectives Apigenin is known to have various pharmacological
properties without causing significant toxicity; however, hepatoprotective effect of apigenin is …

Formulation and biopharmaceutical evaluation of supersaturatable self-nanoemulsifying drug delivery systems containing silymarin

NT Tung, CS Tran, HA Nguyen, TD Nguyen… - International journal of …, 2019 - Elsevier
The first objective of this study was to optimize a supersaturatable self-nanoemulsifying drug
delivery system (S-SNEDDS) containing silymarin through the investigation of the single and …

Devices and techniques used to obtain and analyze three‐dimensional cell cultures

G Agrawal, A Ramesh, P Aishwarya… - Biotechnology …, 2021 - Wiley Online Library
Cell cultures are indispensable for both basic and applied research. Advancements in cell
culture and analysis increase their utility for basic research and translational applications. A …

Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway

Y Xue, Q Deng, Q Zhang, Z Ma, B Chen, X Yu… - Scientific Reports, 2020 - nature.com
Arachidonic acid (AA) signaling pathway is an important constituent of inflammatory
processes. In our previous study, it was found that dihydro-stilbene gigantol relieved hepatic …