Oligodendrocytes are the myelinating cells of the central nervous system (CNS) that are
generated from oligodendrocyte progenitor cells (OPC). OPC are distributed throughout the …

Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …

Neonatal engraftment by oligodendrocyte progenitor cells (OPCs) permits the myelination of
the congenitally dysmyelinated brain. To establish a potential autologous source of these …

Central nervous system (CNS) myelination by oligodendrocytes (OLs) is a highly
orchestrated process involving well-defined steps from specification of neural stem cells into …

The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are
coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on …

Neuroglia critically shape the brain´ s response to ischemic stroke. However, their
phenotypic heterogeneity impedes a holistic understanding of the cellular composition of the …

Impaired function/differentiation of progenitor cells might provide an explanation for the
limited remyelination observed in the majority of chronic multiple sclerosis lesions. Here, we …

The transcriptional control of CNS myelin gene expression is poorly understood. Here we
identify gene model 98, which we have named myelin gene regulatory factor (MRF), as a …

Oligodendrocytes and the myelin they produce are a remarkable vertebrate specialization
that enables rapid and efficient nerve conduction within the central nervous system. The …

The myelination of axons is a crucial step during vertebrate central nervous system (CNS)
development, allowing for rapid and energy efficient saltatory conduction of nerve impulses …