The opioid G-protein coupled receptors (GPCRs) strongly modulate many of the central
nervous system structures that contribute to major neurological and psychiatric disorders …

The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic
motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many …

Connectomics allows map** of cells and their circuits at the nanometer scale in volumes
of approximately 1 mm 3. Given that the human cerebral cortex can be 3 mm in thickness …

Long-term potentiation (LTP) is a cellular mechanism of learning and memory that results in
a sustained increase in the probability of vesicular release of neurotransmitter. However …

Placozoa is a phylum of non-bilaterian marine animals. These small, flat organisms adhere
to the substrate via their densely ciliated ventral epithelium, which mediates mucociliary …

Postsynaptic densities (PSDs) are large protein complexes associated with the postsynaptic
membrane of excitatory synapses important for synaptic function including plasticity …

Neuromuscular transmission is the process by which motor neurons activate muscle
contraction and thus plays an essential role in generating the purposeful body movements …

Super-resolution microscopy provides valuable insight for understanding the nanoscale
organization within living tissue, although this method is typically restricted to cultured or …

Accurate signal transmission between neurons is accomplished by vesicle release with high
spatiotemporal resolution in the central nervous system. The vesicle release occurs mainly …

This report integrates knowledge of in situ macromolecular structures and synaptic protein
biochemistry to propose a unified hypothesis for the regulation of certain vesicle trafficking …