The germ-cell tumours are a fascinating group of neoplasms because of their unusual
biology and the spectacular therapeutic results that have been obtained in these tumours …

Gonadal germ cell tumors continue to be the cause of diverse, diagnostically challenging
issues for the pathologist, and their correct resolution often has major important therapeutic …

PAX8 is a paired-box gene important in embryogenesis of the thyroid, Müllerian, and
renal/upper urinary tracts, and expression of PAX8 has been previously described in …

Abstract Background: Updated National Academy of Clinical Biochemistry (NACB)
Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been …

The POU-domain transcription factor Oct-4 is normally expressed in pluripotent cells of the
mammalian embryo. In addition, germ-cell tumors and a few somatic tumors show …

The risk for the development of germ cell tumors is an important factor to deal with in the
management of patients with disorders of sex development (DSD). However, this risk is often …

Human embryonic stem cells (HESCs) are the in vitro descendants of the pluripotent inner
cell mass (ICM) of human blastocyst stage embryos. HESCs can be kept undifferentiated in …

This review provides the reader with current insights on testicular adrenal rest tumors
(TARTs), a complication in male patients with congenital adrenal hyperplasia (CAH). In …

The human OCT4 gene can generate at least three transcripts (OCT4A, OCT4B, and
OCT4B1) and four protein isoforms (OCT4A, OCT4B-190, OCT4B-265, and OCT4B-164) by …

Histone modification determines epigenetic patterns of gene expression with methylation of
histone H3 at lysine 4 (H3K4) often associated with active promoters. LSD1/KDM1 is a …