Engineering the next generation of cell-based therapeutics

CJ Bashor, IB Hilton, H Bandukwala… - Nature Reviews Drug …, 2022 - nature.com
Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

Stimuli‐responsive nanocomposite hydrogels for biomedical applications

P Lavrador, MR Esteves, VM Gaspar… - Advanced Functional …, 2021 - Wiley Online Library
The complex tissue‐specific physiology that is orchestrated from the nano‐to the
macroscale, in conjugation with the dynamic biophysical/biochemical stimuli underlying …

Deep brain stimulation by blood–brain-barrier-crossing piezoelectric nanoparticles generating current and nitric oxide under focused ultrasound

T Kim, HJ Kim, W Choi, YM Lee, JH Pyo, J Lee… - Nature Biomedical …, 2023 - nature.com
Deep brain stimulation via implanted electrodes can alleviate neuronal disorders. However,
its applicability is constrained by side effects resulting from the insertion of electrodes into …

Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window

X Wu, Y Jiang, NJ Rommelfanger, F Yang… - Nature Biomedical …, 2022 - nature.com
Neural circuitry is typically modulated via invasive brain implants and tethered optical fibres
in restrained animals. Here we show that wide-field illumination in the second near-infrared …

Prussian blue nanozyme as a pyroptosis inhibitor alleviates neurodegeneration

X Ma, J Hao, J Wu, Y Li, X Cai, Y Zheng - Advanced Materials, 2022 - Wiley Online Library
Current pharmacological interventions for Parkinson's disease (PD) remain unsatisfactory in
clinical settings. Inflammasome‐mediated pyroptosis represents a potential therapeutic …

Mucosa-interfacing electronics

K Nan, VR Feig, B Ying, JG Howarth, Z Kang… - Nature Reviews …, 2022 - nature.com
The surface mucosa that lines many of our organs houses myriad biometric signals and,
therefore, has great potential as a sensor–tissue interface for high-fidelity and long-term …

Wireless and battery-free technologies for neuroengineering

SM Won, L Cai, P Gutruf, JA Rogers - Nature Biomedical Engineering, 2023 - nature.com
Tethered and battery-powered devices that interface with neural tissues can restrict natural
motions and prevent social interactions in animal models, thereby limiting the utility of these …

Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

S Chen, AZ Weitemier, X Zeng, L He, X Wang, Y Tao… - Science, 2018 - science.org
Optogenetics has revolutionized the experimental interrogation of neural circuits and holds
promise for the treatment of neurological disorders. It is limited, however, because visible …

Self-rectifying magnetoelectric metamaterials for remote neural stimulation and motor function restoration

JC Chen, G Bhave, F Alrashdan, A Dhuliyawalla… - Nature materials, 2024 - nature.com
Magnetoelectric materials convert magnetic fields into electric fields. These materials are
often used in wireless electronic and biomedical applications. For example …

Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G **… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …