Sickle cell anemia (SCA) is an inherited blood disorder that causes painful crises due to
vaso-occlusion of small blood vessels. The primary cause of the clinical phenotype of SCA is …

Throughout history, capillary systems have aided the establishment of the fundamental laws
of blood flow and its non-Newtonian properties. The advent of microfluidics technology in the …

The spleen clears altered red blood cells (RBCs) from circulation, contributing to the balance
between RBC formation (erythropoiesis) and removal. The splenic RBC retention and …

BACKGROUND: In sickle cell disease (SCD), polymerization of hemoglobin S (HbS) leads
to the formation of rigid, non-deformable sickled RBCs. Loss of RBC deformability, sickling …

The clearance of senescent and altered red blood cells (RBCs) in the red pulp of the human
spleen involves sequential processes of prefiltration, filtration, and postfiltration. While prior …

Dissipative particle dynamics (DPD) is an effective Lagrangian method for modeling
complex fluids in the mesoscale regime but so far it has been limited to relatively simple …

Erythrocytes in patients with type-2 diabetes mellitus (T2DM) are associated with reduced
cell deformability and elevated blood viscosity, which contribute to impaired blood flow and …

We present OpenRBC, a coarse-grained molecular dynamics code, which is capable of
performing an unprecedented in silico experiment—simulating an entire mammal red blood …

Platelet transport through arterial constrictions is one of the controlling processes influencing
their adhesive functions and the formation of thrombi. We perform high-fidelity mesoscopic …

Large-scale simulations of blood flow that resolve the 3D deformation of each comprising
cell are increasingly popular owing to algorithmic developments in conjunction with …