ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
A key objective in the field of translational psychiatry over the past few decades has been to
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …
identify the brain correlates of major depressive disorder (MDD). Identifying measurable …
Is subthreshold depression in adolescence clinically relevant?
Background Subthreshold depression is highly prevalent in adolescence, but compared to
major depressive disorder, the clinical impact is under-researched. The aim of this review …
major depressive disorder, the clinical impact is under-researched. The aim of this review …
[HTML][HTML] Light affects mood and learning through distinct retina-brain pathways
Light exerts a range of powerful biological effects beyond image vision, including mood and
learning regulation. While the source of photic information affecting mood and cognitive …
learning regulation. While the source of photic information affecting mood and cognitive …
Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression
Importance Late-life depression (LLD) is characterized by considerable heterogeneity in
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …
Toward circuit mechanisms of pathophysiology in depression
T Spellman, C Liston - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
The search for more effective treatments for depression is a long-standing primary objective
in both psychiatry and translational neuroscience. From initial models centered on …
in both psychiatry and translational neuroscience. From initial models centered on …
Hippocampal and amygdalar volume changes in major depressive disorder: a targeted review and focus on stress
M Nolan, E Roman, A Nasa, KJ Levins… - Chronic …, 2020 - journals.sagepub.com
Medial temporal lobe structures have long been implicated in the pathogenesis of major
depressive disorder. Although findings of smaller hippocampal and amygdalar volumes are …
depressive disorder. Although findings of smaller hippocampal and amygdalar volumes are …
[HTML][HTML] Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder
Inflammatory processes are implicated in the aetiology of Major Depressive Disorder (MDD);
however, the relationship between peripheral inflammation, brain structure and depression …
however, the relationship between peripheral inflammation, brain structure and depression …
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
Depression is a leading cause of worldwide disability but there remains considerable
uncertainty regarding its neural and behavioural associations. Here, using non-overlap** …
uncertainty regarding its neural and behavioural associations. Here, using non-overlap** …
Grey and white matter microstructure is associated with polygenic risk for schizophrenia
Recent discovery of approximately 270 common genetic variants associated with
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
schizophrenia has enabled polygenic risk scores (PRS) to be measured in the population …
Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease
C Ferrari Bardile, M Garcia-Miralles… - Proceedings of the …, 2019 - National Acad Sciences
White matter abnormalities are a nearly universal pathological feature of neurodegenerative
disorders including Huntington disease (HD). A long-held assumption is that this white …
disorders including Huntington disease (HD). A long-held assumption is that this white …