Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with
synovial tissue proliferation, pannus formation, cartilage destruction, and systemic …

IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …

The microbiota modulates gut immune homeostasis. Bacteria influence the development
and function of host immune cells, including T helper cells expressing interleukin-17A (TH17 …

Non-coding genetic variants may cause disease by modulating gene expression. However,
identifying these expression quantitative trait loci (eQTLs) is complicated by differences in …

Rheumatoid arthritis is a heterogeneous disease, which can be, based on data combining
genetic risk factors and autoantibodies, sub-classified into ACPA-positive and-negative RA …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …

Abstract IL-17-producing T helper (Th17) cells have been implicated in the pathogenesis of
many inflammatory and autoimmune diseases. Targeting the effector cytokines IL-17 and …

Programmed cell death is regulated by evolutionarily conserved pathways that play critical
roles in development and the immune response. A newly recognized pathway for …

Since the molecular cloning of interleukin-6 (IL-6) in 1986, many other cytokines have been
found to share the same signal transducer, gp130, in their receptor complexes. Thus, the IL …