Multidrug-resistant Gram-negative bacterial infections are exponentially increasing, posing
one of the most urgent global healthcare and economic threats. Due to the lack of new …

An overuse of antibiotics both in human and animal health and as growth promoters in
farming practices has increased the prevalence of antibiotic resistance in bacteria. Antibiotic …

Acinetobacter baumannii is a gram-negative bacterial pathogen that causes challenging
nosocomial infections. β-lactam targeting of penicillin-binding protein (PBP)–mediated cell …

Phage have gained renewed interest as an adjunctive treatment for life-threatening
infections with the resistant nosocomial pathogen Acinetobacter baumannii. Our …

Advanced glycation end-products (AGE) are a pervasive form of protein damage implicated
in the pathogenesis of neurodegenerative disease, atherosclerosis and diabetes mellitus …

Cariogenic Streptococcus mutans (S. mutans) is a leading cause of bacterial-induced oral
diseases. Current strategies to kill bacteria based on Host defense peptide (HDP) mimicking …

Insect defensins are a large family of antimicrobial peptides primarily active against Gram-
positive bacteria. Here, we explore their hidden anti-Gram-negative bacterial potential via a …

Millions of deaths a year across the globe are linked to antimicrobial resistant infections. The
need to develop new treatments and repurpose of existing antibiotics grows more pressing …

During growth, bacteria remodel and recycle their peptidoglycan (PG). A key family of PG-
degrading enzymes is the lytic transglycosylases, which produce anhydromuropeptides, a …

There is an urgent need to develop efficient and safe antimicrobials to augment traditional
antibiotics for fighting drug-resistant bacteria. Antimicrobial photodynamic therapy (aPDT), is …