The plasminogen system has been implicated in clot lysis, wound healing, tissue
regeneration, cancer and many other processes that affect health and disease. The …

Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

Bone development and remodeling depend on complex interactions between bone-forming
osteoblasts and other cells present within the bone microenvironment, particularly vascular …

Elevated expression of plasminogen activator inhibitor-1 (PAI-1) in tumors is associated with
a poor prognosis in many cancers. Reduced tumor growth and angiogenesis have also …

Extracellular proteolysis is an absolute requirement for new blood vessel formation, a
process known as angiogenesis. This review will examine the role of the matrix …

Introduction‐Evidence for endothelial disease and loss of capillaries in SSc‐Angiogenesis
and vasculogenesis• Mechanisms and biomarkers of endothelial damage in SSc• …

The urokinase-type plasminogen activator receptor (uPAR) is involved in the regulation of
cell motility in a variety of cell types. We show here that expression of human uPAR in …

Vascular endothelium—lining the inner side of blood bessels—is one of the largest
secretory tissues of the body. Therefore, understanding the cellular and molecular biology of …

Abstract Systemic Sclerosis (SSc) pathogenesis involves multiple immunological, vascular
and fibroproliferative abnormalities that contribute to a severe and complex clinical picture …

Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type
plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is …