Gut microbiome–brain alliance: a landscape view into mental and gastrointestinal health and disorders

JM Sasso, RM Ammar, R Tenchov… - ACS Chemical …, 2023 - ACS Publications
Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

The neurobiology of irritable bowel syndrome

EA Mayer, HJ Ryu, RR Bhatt - Molecular psychiatry, 2023 - nature.com
Irritable bowel syndrome (IBS) is the most prevalent disorder of brain-gut interactions that
affects between 5 and 10% of the general population worldwide. The current symptom …

Irritable bowel syndrome and mental health comorbidity—approach to multidisciplinary management

HM Staudacher, CJ Black, SB Teasdale… - Nature Reviews …, 2023 - nature.com
Irritable bowel syndrome (IBS) affects 5–10% of the global population. Up to one-third of
people with IBS also experience anxiety or depression. Gastrointestinal and psychological …

Gene discovery and biological insights into anxiety disorders from a large-scale multi-ancestry genome-wide association study

E Friligkou, S Løkhammer, B Cabrera-Mendoza… - Nature …, 2024 - nature.com
We leveraged information from more than 1.2 million participants, including 97,383 cases, to
investigate the genetics of anxiety disorders across five continental groups. Through …

[HTML][HTML] Genomic analyses of hair from Ludwig van Beethoven

TJA Begg, A Schmidt, A Kocher, MHD Larmuseau… - Current Biology, 2023 - cell.com
Summary Ludwig van Beethoven (1770–1827) remains among the most influential and
popular classical music composers. Health problems significantly impacted his career as a …

Role of the gut-brain axis in the shared genetic etiology between gastrointestinal tract diseases and psychiatric disorders: A genome-wide pleiotropic analysis

W Gong, P Guo, Y Li, L Liu, R Yan, S Liu… - JAMA …, 2023 - jamanetwork.com
Importance Comorbidities and genetic correlations between gastrointestinal tract diseases
and psychiatric disorders have been widely reported, with the gut-brain axis (GBA) …

Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis

M Tesfaye, P Jaholkowski, GFL Hindley, AA Shadrin… - Genome Medicine, 2023 - Springer
Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and
gastrointestinal disorders. A recent genome-wide association study (GWAS) identified …

The gut microbiome in disorders of gut–brain interaction

N Kraimi, T Ross, J Pujo, G De Palma - Gut Microbes, 2024 - Taylor & Francis
Functional gastrointestinal disorders (FGIDs), chronic disorders characterized by either
abdominal pain, altered intestinal motility, or their combination, have a worldwide …

Assessing the relationship between gut microbiota and irritable bowel syndrome: a two-sample Mendelian randomization analysis

B Liu, D Ye, H Yang, J Song, X Sun, Z He, Y Mao… - BMC …, 2023 - Springer
Background Growing evidence has suggested that gut microbiota is closely related to the
risk of irritable bowel syndrome (IBS), but whether there is a causal effect remains unknown …

A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior

L Cheng, H Wu, X Cai, Y Zhang, S Yu, Y Hou, Z Yin… - Cell Host & Microbe, 2024 - cell.com
Gene-environment interactions shape behavior and susceptibility to depression. However,
little is known about the signaling pathways integrating genetic and environmental inputs to …