We present a new estimator for computing free energy differences and thermodynamic
expectations as well as their uncertainties from samples obtained from multiple equilibrium …

Soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE) proteins
drive membrane fusion by assembling into a four-helix bundle in a zippering process. Here …

Protein folding occurs as a set of transitions between structural states within an energy
landscape. An oversimplified view of the folding process emerges when transiently …

Optical tweezers have become one of the primary weapons in the arsenal of biophysicists,
and have revolutionized the new field of single-molecule biophysics. Today's techniques …

Biomolecules are the prime information processing elements of living matter. Most of these
inanimate systems are polymers that compute their own structures and dynamics using as …