A paradigm shift in imaging biomarkers in neovascular age-related macular degeneration

U Schmidt-Erfurth, SM Waldstein - Progress in Retinal and eye Research, 2016 - Elsevier
Neovascular age-related macular degeneration (AMD) has undergone substantial break-
throughs in diagnostic as well as therapeutic respect, with optical coherence tomography …

A view of the current and future role of optical coherence tomography in the management of age-related macular degeneration

U Schmidt-Erfurth, S Klimscha, SM Waldstein… - Eye, 2017 - nature.com
Optical coherence tomography (OCT) has become an established diagnostic technology in
the clinical management of age-related macular degeneration (AMD). OCT is being used for …

[HTML][HTML] Machine learning to analyze the prognostic value of current imaging biomarkers in neovascular age-related macular degeneration

U Schmidt-Erfurth, H Bogunovic, A Sadeghipour… - Ophthalmology …, 2018 - Elsevier
Purpose To evaluate the potential of machine learning to predict best-corrected visual acuity
(BCVA) outcomes from structural and functional assessments during the initiation phase in …

Prediction of anti-VEGF treatment requirements in neovascular AMD using a machine learning approach

H Bogunović, SM Waldstein, T Schlegl… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: The purpose of this study was to predict low and high anti-VEGF injection
requirements during a pro re nata (PRN) treatment, based on sets of optical coherence …

Morphology and visual acuity in aflibercept and ranibizumab therapy for neovascular age-related macular degeneration in the VIEW trials

SM Waldstein, C Simader, G Staurenghi, NV Chong… - Ophthalmology, 2016 - Elsevier
Purpose To compare the efficacy of intravitreal aflibercept and ranibizumab on the exudative
activity of neovascular age-related macular degeneration (nAMD) using optical coherence …

[HTML][HTML] Machine learning of the progression of intermediate age-related macular degeneration based on OCT imaging

H Bogunović, A Montuoro, M Baratsits… - … & visual science, 2017 - tvst.arvojournals.org
Purpose: To develop a data-driven interpretable predictive model of incoming drusen
regression as a sign of disease activity and identify optical coherence tomography (OCT) …

Expert-level automated biomarker identification in optical coherence tomography scans

T Kurmann, S Yu, P Márquez-Neila, A Ebneter… - Scientific reports, 2019 - nature.com
In ophthalmology, retinal biological markers, or biomarkers, play a critical role in the
management of chronic eye conditions and in the development of new therapeutics. While …

Predicting macular edema recurrence from spatio-temporal signatures in optical coherence tomography images

WD Vogl, SM Waldstein, BS Gerendas… - IEEE transactions on …, 2017 - ieeexplore.ieee.org
Prediction of treatment responses from available data is key to optimizing personalized
treatment. Retinal diseases are treated over long periods and patients' response patterns …

[HTML][HTML] Analyzing and predicting visual acuity outcomes of anti-VEGF therapy by a longitudinal mixed effects model of imaging and clinical data

WD Vogl, SM Waldstein, BS Gerendas… - … & Visual Science, 2017 - jov.arvojournals.org
Purpose: We develop a longitudinal statistical model describing best-corrected visual acuity
(BCVA) changes in anti-VEGF therapy in relation to imaging data, and predict the future …

Multivendor spectral‐domain optical coherence tomography dataset, observer annotation performance evaluation, and standardized evaluation framework for …

J Wu, AM Philip, D Podkowinski… - Journal of …, 2016 - Wiley Online Library
Development of image analysis and machine learning methods for segmentation of clinically
significant pathology in retinal spectral‐domain optical coherence tomography (SD‐OCT) …