Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

The extracellular matrix (ECM) is composed of highly variable and dynamic components that
regulate cell behavior. The protein composition and physical properties of the ECM govern …

Epithelial-to-mesenchymal transition (EMT) increases cell migration and invasion, and
facilitates metastasis in multiple carcinoma types, but belies epithelial similarities between …

Hyaluronan, a major macropolysaccharide in the extracellular matrix of connective tissues,
is intimately involved in the biology of cancer. Hyaluronan accumulates into the stroma of …

Glycosaminoglycans are major constituents of the cancer cell surface and the tumor stroma.
The heparan sulfate degrading enzyme heparanase, hyaluronan, and its receptor CD44 are …

Cancer stem cells (CSCs) represent a unique subpopulation of self-renewing oncogenic
cells that drive cancer initiation and progression. CSCs often acquire multidrug and …

Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an
unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth and …

The tightly regulated biosynthesis and catabolism of the glycosaminoglycan hyaluronan, as
well as its role in organizing tissues and cell signaling, is crucial for the homeostasis of …