The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Astrocytes comprise half of the cells in the central nervous system and play a critical role in
maintaining metabolic homeostasis. Metabolic dysfunction in astrocytes has been indicated …

Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although
poor delivery to the brain hinders their therapeutic application. In the current study, it is …

Amino acid dysregulation has emerged as an important driver of disease progression in
various contexts. l-Serine lies at a central node of metabolism, linking carbohydrate …

Astrocytes are the most abundant cells in the brain. They have many important functions in
the central nervous system (CNS), including the maintenance of glutamate and ion …

Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine
stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network …

Serine metabolism promotes tumor oncogenesis and regulates immune cell functions, but
whether it also contributes to antiviral innate immunity is unknown. Here, we demonstrate …

Astrocytes are critical regulators of CNS function and are proposed to be heterogeneous in
the develo** brain and spinal cord. Here we identify a population of astrocytes located in …

The non-essential amino acid serine is a critical nutrient for cancer cells due to its diverse
biosynthetic functions. While some tumors can synthesize serine de novo, others are …

Astrocytes express the 3-phosphoglycerate dehydrogenase (Phgdh) enzyme required for
the synthesis of l-serine from glucose. Astrocytic l-serine was proposed to regulate NMDAR …