Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …

Viral infections play an important role in human diseases, and recent outbreaks in the
advent of globalization and ease of travel have underscored their prevention as a critical …

The use of medicinal plants in treating illnesses has been reported since ancestral times. In
the case of hepatic diseases, several species such as Silybum marianum, Phyllanthus niruri …

Herbal products are increasingly used, mainly in chronic liver disease. Extracts of milk
thistle, Silymarin and silybin, are the most prescribed natural compounds, with different …

The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Widespread use of herbal drugs because of their protective effects on different organs
toxicity has been shown in many studies. These protective effects have been illustrated in …

The liver is the center for drug and xenobiotic metabolism, which is influenced most with
medication/xenobiotic-mediated toxic activity. Drug-induced hepatotoxicity is common and …

Silymarin, also known as milk thistle extract, inhibits hepatitis C virus (HCV) infection and
also displays antioxidant, anti-inflammatory, and immunomodulatory actions that contribute …

Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …

The only currently recommended treatment for nonalcoholic fatty liver disease (NAFLD) is
lifestyle modification. Preliminary studies of silybin showed beneficial effects on liver …