Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

RA Nixon, DC Rubinsztein - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …

Natural autophagy modulators in non-communicable diseases: from autophagy mechanisms to therapeutic potential

T Xu, Y Deng, X Yu, M Li, Y Fu - Acta Pharmacologica Sinica, 2024 - nature.com
Non-communicable diseases (NCDs) are defined as a kind of diseases closely related to
bad behaviors and lifestyles, eg, cardiovascular diseases, cancer, and diabetes. Driven by …

ATG9A facilitates the closure of mammalian autophagosomes

R Javed, M Mari, E Trosdal, T Duque, MA Paddar… - Journal of Cell …, 2025 - rupress.org
Canonical autophagy captures within specialized double-membrane organelles, termed
autophagosomes, an array of cytoplasmic components destined for lysosomal degradation …

Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function

MA Paddar, F Wang, ES Trosdal, E Hendrix, Y He… - Elife, 2025 - elifesciences.org
ATG5 is one of the core autophagy proteins with additional functions such as noncanonical
membrane atg8ylation, which among a growing number of biological outputs includes …

[HTML][HTML] Molecular Mechanisms Underlying Initiation and Activation of Autophagy

Z Wei, X Hu, Y Wu, L Zhou, M Zhao, Q Lin - Biomolecules, 2024 - mdpi.com
Autophagy is an important catabolic process to maintain cellular homeostasis and
antagonize cellular stresses. The initiation and activation are two of the most important …

ATG9 promotes autophagosome formation through interaction with LC3

P Xu, T Zhang, F Yu, L Guo, Y Yang - Biochemical and Biophysical …, 2025 - Elsevier
The autophagosome is a double-membrane organelle that executes macroautophagy.
Previous studies have shown that the autophagosome formation is driven by autophagy …

[HTML][HTML] Bridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM

MG Hanna, HOR Cruz, K Fujise, Z Li, M Monetti… - …, 2024 - pmc.ncbi.nlm.nih.gov
Recent studies have identified a family of rod-shaped proteins which includes VPS13 and
ATG2 and are thought to mediate unidirectional lipid transport at intracellular membrane …

The food grade bacterium Lactobacillus helveticus VEL12193 promotes autophagy by releasing membrane vesicles

MA Bringer, J Al Azzaz, B Buteau, L Proukhnitzky… - bioRxiv, 2024 - biorxiv.org
Autophagy-related processes, including canonical macroautophagy, are crucial for
maintaining cellular homeostasis in eukaryotic organisms. Alterations or reduced activity of …

Mechanisms of Autophagy–Lysosome Dysfunction in Neurodegenerative Diseases

D Rubinsztein, R Nixon - 2024 - repository.cam.ac.uk
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their post …

[CITATION][C] Molecular mechanisms and physiological functions of autophagy

F Wilfling, M Graef - Journal of Molecular Biology, 2024 - pure.mpg.de
Molecular Mechanisms and Physiological Functions of Autophagy :: MPG.PuRe English Help
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