Metalloenzymes are central to the regulation of a wide range of essential viral and parasitic
functions, including protein degradation, nucleic acid modification, and many others. Given …

Ribonucleases (RNases) cleave and process RNAs, thereby regulating the biogenesis,
metabolism, and degradation of coding and noncoding RNAs. Thus, small molecules …

Fragment-based drug discovery (FBDD) is a powerful strategy for the identification of new
bioactive molecules. FBDD relies on fragment libraries, generally of modest size, but of high …

Enzymes are common targets in high-throughput screening and related campaigns. An
analysis of papers published between 1990 and 2018 showed that kinases were the most …

Fragment-based drug discovery (FBDD) has grown and matured to a point where it is
valuable to keep track of its extent and details of application. This Perspective summarizes …

The SARS-CoV-2 virus is a major problem in the world right now. Currently, all the attention
of research centers and governments globally are focused on the investigation of …

Human carbonic anhydrase II (hCAII) is a metalloenzyme essential to critical physiological
processes in the body. hCA inhibitors are used clinically for the treatment of indications …

Abstract BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole
world, is the most important disease of the world today. Many ways to inhibit SARS-CoV-2 …

1, 4-Dihydropyridines (1, 4-DHPs) hold a top-notch position in the pharmaceutical world due
to a broader spectrum of applications, whereas the carboxylic moiety has been an integral …

Hydroxypyranone and hydroxypyridinone are important oxygen-containing or nitrogen-
containing heterocyclic nucleus and attracted increasing attention in medicinal chemistry …